TO ENHANCE THE SOLUBILITY OF CURCUMIN BY SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS).
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract This study was performed to develop and characterize a novel solid self- microemulsifying drug delivery system of class IV drug curcumin by spray drying method using Aerosil 200 as the solid carrierfor the purpose of solubility enhancement of curcumin. Solubility of curcumin was determined in various vehicles, including oils, surfactants and co-surfactants. The compatibility study was performed by IR and DSC. Pseudo-ternary phase diagrams were constructed to identify the most efficient self-emulsification region. The optimized liquid SMEDDS for curcumin formulation contained of oil capryol 90, surfactant kolliphor TPGS and co-surfactant PEG 400 in the ratio 3:1:1. The optimum liquid SMEDDS consisted of 4% curcumin, 60% capryol 90, 20% kolliphor TPGS and 20% PEG 400. Solid SMEDDS were also evaluated for flow properties like angle of repose, Hausner’s ratio, Carr’s index, bulk density and tapped density. The curcumin liquid and solid SMEDDS formulation rapidly formed fine oil-in-water microemulsion with mean globule size 153±7.4 nm and 169±8.2 respectively. The drug formulated in the solid SMEDDS was quickly and completely dissolved (≥90%) within 120 min, both in 0.1N HCl and phosphate buffer pH 6.8 dissolution media, whereas crude curcumin powder was significantly less soluble. The solubility of S-SMEDDS in distilled water was inhanced 151.68 fold and 170.87 fold when determined by UV and HPLC respectively, whereas aqueous solubility of crude curcumin was 0.694μg/ml. This study demonstrates that self-microemulsifying drug delivery system results in significant improvement in solubility and dissolution of very poorly water soluble drug curcumin.
Authors and Affiliations
Mrudula H. Bele*, Ashpak A. Shaikh, Sanket G. Paralkar
Keywords
Related Articles
- EP ID EP330795
- DOI -
- Views 101
- Downloads 0
MONITORING OF ADVERSE DRUG REACTIONS (ADR) IN CHRONIC MYELOID LEUKEMIA (CML) PATIENTS TREATED WITH IMATINIB AT A TERTIARY CARE HOSPITAL
Imatinib is a tyrosine kinase inhibitor and potently inhibits protein tyrosine kinases which include BCR-ABL which is constitutively active in CML. It targets the ATP binding site of receptors. The present investigation...
A REVIEW ON MEDICINAL PLANTS AND HERBAL DRUG FORMULATIONS USED IN DIABETES MELLITUS
Diabetes mellitus is a metabolic disorder in the endocrine system. This dreadful disease is found in all parts of the world and is becoming a serious threat to mankind health. It is caused by the deficiency or ineffectiv...
ISOLATION, PHYSICO-CHEMICAL CHARACTERIZATION AND IN-VITRO DRUG RELEASE STUDIES OF A NOVEL NATURAL POLYSACCHARIDE OF ARAUCARIA HETEROPHYLLA GUM
Abstract Objective: The objective of the present research work for investigation of the physico-chemical, morphological and rheological properties of novel natural polymer, Araucaria heterophylla gum (AHG) and also inves...
Formulation and Evaluation of Perindopril Erbumine Buccal Films
The buccal region of the oral cavity is an attractive target for administration of the drug of choice. To increase bioavailability and prevent first pass metabolism of drug, Perindopril Erbumine was embedded in sustained...
FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM MICROSPHERES BY SOLVENT EVAPORATION METHOD
Abstract Losartan Potassium loaded microspheres were prepared by solvent evaporation method with combination of hydroxy propyl methyl cellulose and Carbopol polymers in various proportions. A total of nine formulations w...