“To evaluate outcome of thrombocytopenia with Dengue Fever”
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 10
Abstract
Despite considerable efforts to control the mosquito populations, dengue fever has emerged, spread and established itself rapidly. The most serious manifestations of the infection are Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Though thrombocytopenia is a distinctive characteristic of dengue, few studies have related thrombocytopenia with its clinical severity. Our research aims to study the clinical profile of patients presenting Dengue fever with thrombocytopenia & to study the outcome of patients with respect to severity of thrombocytopenia in Dengue fever and associated co morbid medical conditions. After taking informed consent, data regarding history, examination & investigations were noted & analysed further. Out of enrolled 127 patients 89(70.08%) patients were male and 38 (29.92%) were females. Mean age of presentation was 26.20 ± 10.92 years. Bleeding Tendency was present in 26 (20.47%) patients . Other complication like Hepatic failure in 7 (5.51 %) patients, Renal failure in 12 (9.44 %) patients , acute respiratory distress syndrome (ARDS) in 9 (7.08%) of patients & Multi Organ Dysfunction Syndrome (MODS) was observed in 7 (5.51 %) patients . Overall 7 (5.51%) patients died during ward stay of which MODS with disseminated intravascular coagulation (DIC) (71%) was the commonest cause of death followed by ARDS. In conclusion , Severe thrombocytopenia was found to be associated with shock, bleeding tendency, anaemia, renal failure, severe hepatic involvement and ARDS to a significant extent.
Authors and Affiliations
Dr. Neelam Redkar, Dr. Nitin Sarate, Dr. Rajit Pillai
Keywords
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