Development and Evaluation of Enteric Coated Herbal Drug Delivery System for Treatment of Asthma
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 12
Abstract
Adhatoda Vasica is a plant believed to have several therapeutic effects including anti-asthmatic properties. The purpose of study was to develop its tablet formulation by direct compression technology for prevention of episodic attack of asthma in early morning. To achieve the objective, formulations containing core immediate release Adhatoda Vasica tablets were prepared by direct compression method using different concentrations (2.5 – 7.5%w/w) of superdisintegrant cross caramellose sodium. Each formulation was characterized in terms of hardness, friability, drug content and in-vitro disintegration time. On the basis of disintegration profile, the selected best formulation was coated with ethyl cellulose as inner layer and Eudragit S100 as outer enteric-coating layer which retards the drug release in stomach but releases the drug immediately in the intestinal pH. The optimized enteric-coated formulation CF6 containing 2.5% w/w of Eudragit S 100 and 25% w/w of ethyl cellulose as coating system inhibited the release of the drug in 0.1 N HCl, and whereas 91.46% of drug was released in the intestinal medium at the end of 10 hrs. Thus, dissolution profiles indicated that CF6 tablet may be better alternative in the treatment of nocturnal asthma which overcomes the problems of conventional forms. The results obtained revealed that developed vasaka formulation exhibited a promising role in release of drug after a lag time which is essential for chronotherapeutic delivery.
Authors and Affiliations
Md Sarfaraz , V. G. Joshi
Keywords
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