TO EVALUATE THE ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF MIKANIA MICRANTHA ON EXPERIMENTAL ANIMAL MODELS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 50
Abstract
BACKGROUND Different parts of the plant Mikania micrantha are traditionally used to treat several diseases like dysentery, body sprain, diabetes, snake bites, itches, gout, flatulence, rheumatism and cancer. Therefore, the present study was undertaken to evaluate the antiinflammatory activity of the Ethanolic Extracts of leaves of Mikania micrantha (EEMM) on carrageenan-induced rat paw oedema, granuloma-pouch method and adjuvant-induced chronic arthritis on experimental animals. MATERIALS AND METHODS Plants of Mikania micrantha were collected from the campus of Assam Medical College, Dibrugarh, Assam. The extract of Mikania micrantha leaves was prepared by percolation method using 95% alcohol. Acute oral toxicity test of the extract was performed as per OECD 423 (OECD Guidelines, 2001). Acute inflammation was studied by carrageenan-induced rat paw oedema method; subacute inflammation was studied by Granuloma pouch method and chronic inflammation was studied by Freund’s complete adjuvant-induced arthritis method. Aspirin 100 mg/kg was taken as a standard drug. A control group is maintained in all the above mentioned models. RESULTS The results were analysed by ANOVA followed by Dunnett’s multiple comparison test. EEMM in doses 200 - 400 mg/kg produced dose dependent and significant (p < 0.05) reduction of paw oedema in carrageenan-induced acute and sub-acute inflammation in comparison to control. EEMM is not effective in chronic arthritis model in dose-dependent manner. CONCLUSION The present study indicates that EEMM has significant anti-inflammatory activity.
Authors and Affiliations
Chinmoyee Deori, Geetamoni Dutta, Swarnamoni Das, Daisy Phukan, Gaurov Gogoi
Keywords
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- EP ID EP219648
- DOI 10.14260/Jemds/2017/825
- Views 190
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