“To Evaluate the Efficacy of Tranexamic Acid in Reducing Blood Loss And Postoperative Blood Transfusions Following Total Knee Replacement “
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Background: Blood loss in TKA(Total Knee Arthroplasty) patients is multifactorial. Ischemia increases fibrinolysis, related to the proteolytic action of plasmin, with subsequent fibrinogen scission which limits postoperative coagulation and favours bleeding. Aims: This study was designed to assess the efficacy of Tranexamic Acid (TXA) in reducing blood loss and postoperative blood transfusions following TKR. Settings and Design: Randomized, prospective and comparative study Methods and Material: In this study, patients were randomly allocated into two groups of 25 each. Group I received Inj Tranexamic Acid before inflation of tourniquet and Group II received inj normal saline. Preoperative hemoglobin, postoperative hemoglobin, Total blood volume, Blood loss and hemoglobin loss is compared between two groups. . Statistical Analysis: Mean and standard deviation was calculated. The quantitative variables were compared with Fischer’s t-test and comparison of qualitative variables was performed by Fisher’s exact test. Results and Conclusion: The mean blood loss in TXA and placebo group was 392.02 194.33 ml and 980.25 295.35 ml respectively and found to be highly significant(P-value < 0.001). Number of patients required blood transfusion are significantly low in TXA group than Placebo Group. ( P< .01)
Authors and Affiliations
Dr. Prateek Singh Bais, Dr. Amit Tyagi, Dr. Manoj Tripathi, Dr. Aamir Laique Khan, Dr. Sharanu Patil, Dr. Mahendra Singh
Keywords
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- EP ID EP243704
- DOI 10.9790/0853-1610064852
- Views 88
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