To evaluate the in vitro transcorneal penetration of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin in the presence and absence of amniotic membrane using goat cornea
Journal Title: Journal of Indira Gandhi Institute of Medical Sciences - Year 2017, Vol 3, Issue 2
Abstract
Abstract This study was intended to evaluate the in vitro transcorneal penetration of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin in the presence and absence of amniotic membrane using goat cornea. This was an experimental study to estimate transcorneal penetration of four 0.3% fluoroquinolone formulations. In the absence of amniotic membrane, the calculated flux of the transfer in case of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin 0.3% were found to be 2.41µg/cm2/hr, 4.45 µg/cm2/hr, 7.4 µg/cm2/hr and 0.968 µg/cm2/hr respectively. In the presence of amniotic membrane these values changed to 3.38 µg/cm2/hr, 2.15µg/cm2/hr, 5.75 µg/cm2/hr and 2.4 µg/cm2/hr respectively. The transcorneal permeation studies using goat cornea showed the cumulative release in the following order as lomefloxacin>pefloxacin>ofloxacin>sparfloxacin.
Authors and Affiliations
Alok Kumar Ravi, Nihar Ranjan Biswas, Thirumurthy Velepandian, Raju Sampangi, Sat Pal Garg, Supriyo Ghose
Keywords
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