To See Correlation of Elevated HBA1C in Hypothyroid Individuals with Anaemia: If Any.
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Glycosylated Hemoglobin A1c (HbA1c) is formed by the glycation of the valine of the β-chain of hemoglobin and used commonly as a screening test for diabetes in clinical practice. (1) ADA endorsed an HbA1c > 6.5% as diagnostic for diabetes. Hence current research aimed to study whether elevated Hba1C in Hypothyroidism has any correlation with anaemia. Material and methods: 140 non diabetic hypothyroid patients were selected and their Hba1C was done (40 microcytic hypochromic anaemia, 40 normocytic normochromic, 60 non anaemia) and 140 age, sex, fasting glucose level and anaemia status matched controls were selected. Diabetes was excluded by doing fasting and post prandial blood sugar levels. We excluded pregnant patients, patients having haemolytic anaemia, other haemoglobinopathies, anaemia due to other chronic illnesses, renal disease that shorten erythrocyte survival may proportionately decrease Hba1C levels and are also associated with iron deficiency. Results: In hypothyroid individuals Hba1C with microcytic hypochromic anaemia and normocytic normochromic anaemia was 6.94 ± 0.28% and 6.29 ± 0.62 while in euthyroid anaemic matched control it was 6.02± 0.26 and 5.24 ± 0.24%. Hypothyroid non anaemic patients showed HbA1c level of 5.28± 0.24% and that of euthyroid it was 5.34±0.48% and patient of Hba1C > 6.5 in hypothyroid patients had significant odds ratio. Diabetes was excluded by doing fasting and post prandial blood sugar levels. Conclusion: Non diabetic hypothyroid patients may show elevated Hba1C of pre diabetic range with anaemia. So in such patients we should take care before making diagnosis of diabetes.
Authors and Affiliations
Gaurav Agarwal, Bhawesh Kumar, Darshan Mehra, Malini Kulshrestha
Keywords
Related Articles
- EP ID EP425486
- DOI -
- Views 112
- Downloads 0
Effect of Various Collagen Cross Linkers on the Bond Strength of Dentin Bonding Agents to the Dentin
Introduction: Improvement of the mechanical properties of type 1 collagen may be advantageous during bonding procedures. So various collagen cross linkers are used in this review which are responsible for modification of...
A Comparitive Study of CA 15.3 Levels in Pre Treated Breast Cancer Patients and Controls
Introduction: Breast cancer is the leading cause of cancer deaths among women worldwide after carcinoma of cervix uteri. CA 15.3 is the chief tumor marker used in the diagnosis of severity of disease and progression from...
A Clinical Study of Collagen Dressing in Partial Thickness Burns
Introduction: Burn injuries are very painful conditions which usually heal slowly and that too with scarring. They are common entities encountered in our daily clinical practice. Dressings play a vital role in the manage...
Inflammation and its Association with Vitamin D in Newly Diagnosed Type 2 Diabetes
Introduction: Deficiency of vitamin D has been associated with increased risk of developing Type 2 diabetes mellitus (DM) and cardiovascular diseases. Vitamin D deficiency is highly prevalent in our country. About 70% of...
Buccal Cell Micronuclei Assay: A Non-Invasive Genotoxic Marker
The introduction of non-invasive and presumptive diagnostic techniques for oral premalignant and malignant lesions in an early stage gave rise to the need for Buccal Cell Micronuclei assay. Formation of micronuclei due t...