To study causality and classify severity of adverse drug reactions of Antitubercular drugs used in patients of DOTS therapy
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Abstract: Adverse drug reactions (ADRs) are considered as one among the leading cause of morbidity and mortality. A general knowledge of the various ADRs and their management is essential for the effective management of Tuberculosis. This study was planned for detection, assessment, classification and causality analysis of ADRs to antitubercular drugs used in DOTS Therapy in Hamidia Hospital, Bhopal and T B Hospital Idgah Hills, Bhopal. Information of the ADRs is data based collected from DOTS center with the help of treating physician and other health care professionals in a specialized performa and the assessment of ADRs done with the help of various scales and investigation. Maximum numbers of ADRs were reported among male population within 4 week of starting DOTS therapy. The causality assessment was found to 50% possible and 30.64% probable. Majority of ADRs 53.22% were moderate, and 46.77% were mild. No severe life threatening ADRs were observed during the study period. We found DOTS therapy safer, but regular monitoring is required for ADRs so as to prevent the ADRs at the initial stage. Keywords:Adverse Drug Reactions (ADRs), antitubercular drugs, DOTS (Directly observed treatment short course) therapy
Authors and Affiliations
Shashi marko, J L marko
Keywords
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