To Study Clinical, Hematological and Neuroimaging Profile in Patients of Infantile Tremor Syndrome in a Rural Based Tertiary Care Centre
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 6
Abstract
Background: Vitamin B12 or cobalamin deficiency is a rare and treatable cause of failure to thrive and delayed development in infants. It is especially more common in infants of vegan mothers. There is a report that every 9 out of 13 mothers are vegan. Studies suggest that the most probable etiology of infantile tremor syndrome is nutritional deficiencies including Vit B12 deficiency. The present study was conducted with the aim to study the clinical, haematological and neuro imaging profile in patients with infantile tremor syndrome amongst patients reporting to a tertiary care hospital. Materials and Methods: The present study was carried in Rural Medical College (PIMS), Loni, Maharashtra. This descriptive cross-sectional study carried out between August 2016 – May 2017. All the patients underwent a complete hematological work-up, prior to the administration of any form of hematinics. Routine hematological tests including hemoglobin estimation, packed cell volume, reticulocyte count, platelet count, total and differential leukocyte count. The peripheral blood film was examined for red cell morphology and neutrophil hypersegmentation. All the results thus obtained were arranged in a tabulated form and analysed using SPSS software. Results: The present study consisted of 13 subjects, out of these there were 6 males and 7 females showing female predominance. The mean age of the subjects was 11 months, with the range of 3-48 months. There were 10 patients (76.9%) who presented with knuckle pigmentation. The mean Haemoglobin was observed to be 4.6 gm/dl, with the range from 1.7 - 5.9 gm/dl. Mean Vitamin B12 level was 385.84 pg/ml with minimum Vitamin B12 level being 159 pg/ml and maximum Vitamin B12 level being 1000 pg/ml. Conclusion: From this study we can conclude that there is association of Infantile tremor syndrome with Vitamin B12 deficiency, as more than 50% of patients in this study had features of megaloblastic anemia.
Authors and Affiliations
Anuj Kumar, (Col) D. Y. Shrikhande, Ekta Singh, Neelanjana De, Shantanu Verma
Keywords
Related Articles
- EP ID EP548464
- DOI 10.21276/ijmrp.2017.3.6.013
- Views 76
- Downloads 0
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