To Study The Cardiovascular And Metabolic Characteristics Of Type-II Diabetes
Journal Title: National Journal of Medical and Dental Research - Year 2018, Vol 6, Issue 3
Abstract
Objectives –Present work aimed to study the cardiovascular / metabolic characteristic of type-2 diabetes and association with cardiovascular correlates of exercise. Material And Method- The present study was conducted in Department of Physiology, GRMC Gwalior & Department Of Biotechnology, Vijayaraje Institute Of Science And Management, Gwalior (MP). The Biochemical investigations were done in the department of Biochemistry of these Institutions. Total of 60 T2DM patients were studied, all patients were examined clinically and systemic examination was done and confirmed by the investigations. All the data collected was statistically confirmed by faculty of SPM. Results - in 60 T2 DM patients aged 40-50 years, 30 patients fell in the age range of 40-50 years with mean age 42.5+1.5 years and remaining 30 patients in age group >45-50years. (48.2+1.42 years.). 50% study population was categorized as normal weight and 50% as overweight, Based on waist circumference measurement abdominal obesity was exhibited by-82% of study population (wc=94.28+6.17cm). According to International diabetes federation (2005) 55% of the study-population categorized as having metabolic syndrome. The duration of disease in 60% of the subjects was < 7years and remaining 40% was more than 7years. Positive family history of diabetes mellitus, hypertension & obesity was found in 78%,45% & 51% of study-population respectively. Majority (63%) of study population were on oral anti-diabetics treatment and 37% were on combined (oral + insulin) therapy. 65% diagnosed cases of hypertension were on antihypertensive treatment (β-Blockers) None of the subjects were having any endocrinal disorder other than diabetes, musculoskeletal disorder and/Orthopaedic impairment. Study of cardiovascular risk factors distribution revealed that the major risk factors in subjects with metabolic syndrome were obesity (Generalized 79%, abdominal 100%), hypertension(100%) dyslipidemia (100%). Physical inactivity (74%) was also found in appreciable number of cases. In subjects without metabolic syndrome abdominal obesity was present in 75% cases, all other risk factors were present in very few cases. In the subjects aged more than forty-five years irrespective of gender, greater prevalence of coronary risk factors was observed. The main risk factors identified in the age group 40-45 years were abdominal obesity (77%) & smoking (53%) and in diabetic patient aged >45-50 years. (48.2+1.42years) were abdominal obesity (87%) hypertension (80%) & physical inactivity (80%). The present study showed that physical inactivity of any-type work related or leisure-time influences health adversely. Increasing trends were observed with increasing body mass index(>25Kg/m2) the prevalence of cardiovascular risk factors viz abdominal obesity (100%), hypertension (90%) metabolic syndrome, physical-inactivity & tobacco-use (67%)in both men & women found in the study population. Lowest prevalence of Hypertension & metabolic syndrome was found in subjects of BMI category (<25 kglm2). Conclusion-Diabetes mellitus is a unique endocrinal disorder, the poor control of which leads to complications involving nearly all the system of human body. It is estimated that large majority of patients with diabetes mellitus type-II or impaired glucose tolerance test have the metabolic syndrome. Presence of metabolic syndrome in these population is associated with higher prevalence of coronary vascular disease than found in patients without metabolic syndrome
Authors and Affiliations
Vikas Jain, Jyoti Jain
Keywords
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