TO STUDY THE CLINICAL AND PATHOLOGICAL STAGING OF BREAST CANCER AND TO CORRELATE THESE FINDINGS WITH STATUS OF THE TUMOR MARKERS
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 4
Abstract
INTRODUCTION : The breast cancer markers that are most important in determining therapy are estrogen receptor, progesterone receptor, and HER-2/neu. Clinicians evaluate clinical and pathologic staging and the expression of estrogen receptor, progesterone receptor, and HER-2/neu in the primary tumor to assess prognosis and assign therapy. AIMS AND OBJECTIVES: To study the clinical and pathological staging of breast cancer and to correlate these findings with status of the tumor markers. MATERIALS AND METHODS: 40 breast cancer patients who attended department of general surgery, King George hospital, Visakhapatnam and referrals from RIMS srikakulam between october20012 to september 2014 were included in this study. All the patients were submitted to detailed clinical examination and investigations including FNAC to confirm the disease and to find out the clinical stageAll the details/data of 40 patients is analyzed to find out whether there is any correlation between clinical staging, pathological staging and tumor markers. An attempt was made to compare the findings of the study with the available Indian and international studies. OBSERVATIONS & RESULTS: In this study majority of the patients presenting with carcinoma breast belong to 5th and 6th decade. Our observation regarding the stage of the disease revealed that stage II and stage III disease was equally distributed. Of the 14 patients in the age group 20-40yrs 7 presented with stage II and remaining 7 with stage III, 10 patients in the age group 41-60yrs presented with stage II disease where as 11 presented with stage IIIdisease. Our observation regarding the stage of the disease revealed that 24 were in pathological stageII and 16 were in stageIII. Majority of the patients(15) were in stage IIB. Majority (23 out of 40) of the patients were presented with pN0 status, 10 with pN1, and 7 with pN2 stage. Clinically node negative cases were 19 out of 40 . But pathologically node negative cases were 23 out of 40. 90% of patients with clinical stage II and stage IIIB were remained in the same stage in pathological staging, where as in stage III A only 50% remained in the same stage .I t is observed that change of clinical stage to pathological stage is due to change in nodal status. CONCLUSION : Majority of the patients were triple negative independent of age, nodal status , clinical , pathological stage and histological type. Testing for ER, PR, Her2neu receptor status was recommended in all patients with breast cancer to facilitate neoadjuvant and adjuvant therapy and for the prognostication.
Authors and Affiliations
DR. SARIPALLI AMMAJI, DR. AKKIDAS. SUVARCHALA, DR. YOGESH
Keywords
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