To Study the Efficacy of Bronchoalveolar Lavage, Bronchial Brush Cytology and Bronchial Biopsy in Diagnosing Lung Cancer
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Lung cancer is one of the most common malignancies amongst the industrialized nations. There are six million new cases of lung cancer which corresponds to 12.7% of the world’s cancer incidence that were diagnosed in 2008. Bronchial brushings for exfoliative cytology use disposable cytology brush, with a diagnostic yield of 72% and 45%, respectively, for central and peripheral lesions. The aim of the present study was to study the efficacy of bronchoalveolar lavage, bronchial brush cytology and bronchial biopsy in diagnosing lung cancer. Material and methods: This Prospective intervention based observational study was conducted among patients attending respiratory OPD at Chatrapati Shivaji Subharti Hospital Meerut, with suspicion of lung cancer, from November 2015 – June 2017. BAL was obtained by introducing a bronchoscope in the lower respiratory tract and specimens obtained by means suction apparatus after infusing 60ml or more saline and re-aspirating it in a MUCUS EXTRACTOR with spare closing cap Materials obtained by broncho-alveolar lavage and brushing were fixed by various fixatives. To take a biopsy sample the bronchoscope tip was taken to the site of visible tumour in the lung. All the data obtained was arranged in a tabulated form and analysed using SPSS software Results: The present study comprised of 40 patients who included 26 males and 14 females. There were 28 smokers and 12 non- smokers. Out of all 40 patients We found that visible endobronchial abnormities were endobronchial growth seen in 28 patients, mucosal infiltration seen in 6 patients and external compression seen in 6 patients. Specificity was 38% in BAL, 44% in brush cytology and 97% in biopsy technique. Positive predictive value was 48.21% in BAL, 88.93% in Brush cytology and 95.26% in biopsy. Conclusion: In this study it was found that BAL fluid, bronchial brush cytology and bronchial biopsy are effective in diagnosing lung cancer.
Authors and Affiliations
Apar Agarwal, Prakhar Sharma, Mahi Saluja, Komal Lohchap, Nitin J ain
Keywords
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