Tooth agenesis in the literature
Journal Title: Forum Ortodontyczne - Year 2014, Vol 10, Issue 2
Abstract
Lack of tooth buds is the most common developmental dental disorder. The incidence of this abnormality in the permanent dentition varies between 0.3% and 17.5%. In the deciduous dentition congenital tooth agenesis is observed significantly more rarely – between 0.08% and 1.55%. Genetic and environmental factors play a role in the aetiology of tooth agenesis. The most important candidate genes the mutations of which are responsible for congenital lack of permanent tooth buds include WNT10A, MSX1, PAX9, EDA, EDAR, EDARADD and AXIN2. Environmental factors include traumas, bone marrow inflammation, intrauterine infection by the rubella virus, chemotherapy and radiation therapy. In clinical practice lack of tooth buds is usually classified as hypodontia, oligodontia and anodontia. The diagnosis of congenital lack of tooth buds can be made where given teeth did not erupt in the oral cavity and they are not present on radiological scans. Both, hypodontia and oligodontia, may be present as single, isolated defects or combined with other geneticallyconditioned disturbances, most frequently dysplasia or ectodermal syndrome. Based on the most recent literature data it can be observed that patients with congenital lack of permanent tooth buds may be at a higher risk of neoplastic diseases, especially colon cancer and ovarian cancer. Therefore, it seems recommended to refer patients with tooth agenesis for screening tests with regard to neoplastic diseases mentioned above. (Zadurska M, Czerkies M, Wasiewicz A, Walerzak M, Laskowska M, Mostowska A. Tooth agenesis in the literature. Orthod Forum 2014; 10: 110-18). Received 2.04.2014 Accepted 28.05.2014
Authors and Affiliations
Małgorzata Zadurska, Martyna Czerkies, Anna Wasiewicz, Monika Walerzak, Adrianna Mostowska
Keywords
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