TOTAL CHOLESTEROL AND HDL RATIO IN NORMOGLYCEMIC OFFSPRING OF PATIENT WITH T2DM ON GRADED EXERCISE
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 10
Abstract
Objectives: The primary causes of Type 2 Diabetes Mellitus (T2DM) are largely unknown but increase in Total Cholesterol and HDL ratio (TC and HDL ratio) has been reported to be a risk factor for the T2DM through the alteration of Lipid Profile (LP). However, it is uncertain if exercise could influence the occurrence of T2DM in offspring of diabetic parents by altering the lipid profile. Therefore this study was designed to assess the effect of exercise on TC and HDL ratio in offspring of T2DM parents compared with offspring of non-diabetic parents. Design: This study involved selection of 42offspring of T2DM parents attending University College Hospital, Ibadan and 53 offspring of non-diabetic parents who are undergraduate students of the University of Ibadan, Nigeria.. Participants were randomly assigned into four groups; 27 Normal-weight Offspring of Non-Diabetic Parents (NONDP), 21 Normal-weight Offspring of Diabetic Parents (NODP), 26 Overweight Offspring of Non-Diabetic Parents (OONDP) and 21 Overweight Offspring of Diabetic Parents (OODP). Each participant followed a protocol of graded exercise using the tummy trimmer everyday spending 30-45 minutes daily for 24 weeks. Blood samples were obtained after an overnight fasting for determination of lipid profile levels at baseline, six week, 12 weeks, 18 weeks and 24 weeks, respectively.The LP determined from the fasting lipid Profile was measured spectrophotometrically using standard laboratory kits supplied by BIOLABO, France. Data were analyzed using descriptive statistic and student t test with significance at p<0.05. Results: After exercise, there were reductions in total cholesterol (mg/dL). There is reduction from 5.45±1.14 to 3.33±0.30 (p<0.05) in OODP from 3.85± 0.42 to 3.26±0.33(p=NS) in NODP from 4.01±0.31 to 3.07±0.16(p<0.05) in OONDP from 4.72±0.40 to 3.94±0.30(p<0.05) in NONDP. There were significant changes in TC and HDL ratio between baseline and at 24 weeks. Conclusions: Graded exercise reduced TC and HDL ratio in all the groups. The clinical importance of graded exercise in prevention of diabetes mellitus along with reducing lipid concentrations, among offspring of diabetic parents looks promising.
Authors and Affiliations
Dr. Taiwo E. O.
Keywords
Related Articles
- EP ID EP657815
- DOI -
- Views 180
- Downloads 0
THE TRANSORAL APPROACH TO CLIVUS AND CERVICAL SPINE: RESURRECTION OF A TECHNIQUE FADING IN TIME
The transoral approach to clivus and upper cervical region is a direct route for treating pathology ventral to the brainstem and upper cervical spinal cord with low morbidity and mortality rates. This approach may be use...
THE EFFECT OF FASTING IN HEALTH AND DISEASE: A SYSTEMATIC REVIEW - 2000 TO 2017
Introduction: The Muslim population worldwide has a higher incidence of cardiovascular disease and the incidence may rise in this population during Ramadan. This review assessed the available published literature that ex...
UNDERSTANDING OF AAM AND ROLE OF AYURVEDIC ANTIOXIDANTS ON IT
In our body, there is a continuous process known as metabolism. During such metabolic changes free radicals are produced by the normal activity of body and are harmful for our body especially as in the long term. They ar...
“EVALUATION OF PLACENTAL THICKNESS AS A SONOLOGICAL INDICATOR FOR ESTIMATION OF GESTATIONAL AGE AND FETAL OUTCOME IN NORMAL SINGLETON PREGNANCY”
Objectives: (1) To correlate placental thickness and fetal weight with gestational age by ultrasonography in normal singleton pregnancy. (2) To evaluate the role of placental thickness in estimation of fetal outcome in t...
BILATERAL PUTAMINAL NECROSIS AND BLINDNESS GIVING LATE FINDING AFTER METHANOL INTAKE: CASE REPORT
The methyl alcohol is a clear, odorless and toxic chemical substance which is found in many products such as antifreeze, defroster solutions, paint removers, and cologne and of which taste is similar to the ethyl alcohol...