Total Phenolic Content, Cytotoxic, Antioxidant, Thrombolytic, Membrane Stabilizing And Antimicrobial Activities of Eupatorium Ayapana Vent.
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 8
Abstract
In the present study, the Kupchan fractions of methanolic extract of Eupatorium ayapana were investigated for total phenolic content, in vitro cytotoxic, antioxidant, thrombolytic, membrane stabilizing and antimicrobial activities. The highest phenolic content was found in carbon tetrachloride soluble partitionate (1.203 mg of GAE / gm of extractives). In the Brine shrimp lethality bioassay, methanol extract revealed the highest activity (LC50 = 0.149 µg/mL) whereas, in thrombolytic activity test, pet-ether soluble partitionate revealed significant value with 15.75 % clot lyses. Among all fractions, the Pet-ether soluble fraction demonstrated highest antioxidant activity (IC50 = 1.67 µg/ml) and in the assay for membrane stabilizing activity, the carbon tetrachloride soluble fraction displayed significant result with 57.61 % and 55.13 % RBC hemolysis in hypotonic solution and heat-induced conditions. Carbon tetrachloride soluble extract exhibited good to excellent inhibitory activity towards microbial growth with average zone of inhibition of 14-29 mm for each species. This is the first report of cytotoxic, DPPH scavenging, thrombolytic and membrane stabilizing activities of different fractions of this plant.
Authors and Affiliations
Israt Zahan Asha, Md. Imdadul Huque Khan, Sanjoy Kumar Mukharjee, Satyajit Roy Rony
Keywords
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