TOXIC AND IMMUNOTOXIC EVALUATION OF KETAMINE AND/OR ETHANOL IN RATS DURING 28 DAYS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 9
Abstract
Objective: Studies have shown that ketamine (K) and ethanol (E) have immunomodulatory activity; however, few studies were performed with concomitant treatments. Thus, we evaluated the toxic and immunotoxic effects of this association.Methods: Wistar rats were distributed into four groups (n=8/group), each receiving one of the following treatments, for 28 d: K group (15 mg/kg of ketamine, intraperitoneally); E group [1.0 ml of ethanol 10% (approximately 0,08g/rat), gavage]; KE group, receiving both treatments; and Control (Co) group, receiving only vehicles. On day 29, animals were euthanized for biochemical, hematological, histopathological and immunological evaluation.Results: Although the experimental conditions did not elicit changes on immune parameters, some biochemical alterations were detected in the different groups. Even in the absence of nutritional and histopathological changes, or renal and hepatic markers that could indicate tissue damage, a reduction on alkaline phosphatase levels in rats from K and KE groups was observed. Moreover, changes in lipid markers [cholesterol, triglycerides and high-density lipoproteins (HDL)] were found in the different groups studied, suggesting that K and E could promote a synergic/antagonistic effect.Conclusion: In conclusion, despite biochemical alterations promoted by K and E, associated or not, the doses here employed did not promote immunotoxic effects on rats treated for 28 d. (response to the suggestion in the end of the paper).Â
Authors and Affiliations
PatrÃcia Franciscone Mendes, Karin Argenti Simon, Isis Machado Hueza
Keywords
Related Articles
- EP ID EP575518
- DOI 10.22159/ijpps.2017v9i9.20582
- Views 48
- Downloads 0
EFFICACY OF LOW-DOSE THROMBOLYSIS WITH INTRAVENOUS ALTEPLASE WITHIN 6 H OF ACUTE ISCHEMIC STROKE ONSET: EVIDENCE FROM SINGLE REFERRAL CENTER IN INDONESIA
Objective: This study evaluated the efficacy of thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke patients within 6 h of stroke onset. Methods: This cross-sectional study collected data of pati...
PHYTOCHEMICALS, ANTIOXIDANT ACTIVITY AND PHENOLIC PROFILING OF DIPLOCYCLOS PALMATUS (L.) C. JEFFERY
Objective: The aim of this study was to analyze phytochemicals, antioxidant potential and phenolic profiling of leaf and fruit extracts of Diplocyclos palmatus.Methods: The leaves and fruits were subjected for sequential...
IMPACT OF tAI IN TRANSLATIONAL DYNAMICS OF HOMO SAPIENS GENES IN ESCHERICHIA COLI GENOME
Objective: Translation of mRNA to protein is a central biological process, and its regulation is vital for cell growth, development and differentiation. It is known that the tRNA molecules play a role of nearly 40% in th...
SPECTROSCOPIC ANALYSIS AND ANTIBACTERIAL EFFICACY OF BIOACTIVE COMPOUNDS FROM LIMONIA ACIDISSIMA L. FRUIT EXTRACT AGAINST CLINICAL PATHOGENS
Objective: To determine the phytochemical composition using spectral analysis and antibacterial activity of Limonia acidissima fruit methanol extract.Methods: Phytochemical analysis was performed to determine the total a...
EFFECT OF COENZYME Q10 ALONE AND ITS COMBINATION WITH ROSUVASTATIN ON STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETIC NEUROPATHY IN RATS
Objectives: This study was aimed to investigate the effect of coenzyme Q10 and its combination with rosuvastatin on STZ-nicotinamide induced diabetic neuropathy.Methods: Diabetic neuropathy in rats were induced with stre...