Toxic epidermal necrolysis associated with combination therapy of spironolactone and torsemide
Journal Title: Journal of Pharmacovigilance and Drug Research - Year 2020, Vol 1, Issue 20201105
Abstract
Dytor plus tablet is a fixed-dose combination of torsemide and spironolactone used for generalized edema. TEN is a serious, potentially life-threatening dermatological disorder. Here we present a case report of a 47-year-old female who was on Dytor Plus (5/50 mg)therapy once daily for generalized edema; presented to dermatology outpatient department with chief complaints of multiple erosions over oral cavity, swelling of lips with scaling, redness and burning sensation in both eyes, multiple well defined mostly erythematous rashes over the entire body since 2 days .on examination, her vital signs were stable and lab result indicate she had elevated SGOT(140 IU/L), SGPT (228 IU/L), ALP (162IU/L) and blood urea(47 mg/ml) values. The patient was diagnosed to have developed Dytor plus induced toxic epidermal necrolysis. Discontinued the medicine and prescribed with Dexamethasone injection, IgG Injection, Cefotaxime injection, Cloxacilline capsule, Cetirizine tablet, Hydroxypropyl methylcellulose eye drop, and candid mouth paint. The patient had a hospital stay of 25 days. The patient improved symptomatically. Causality was assessed as per the WHO-UMC causality scale and this case was put in the probable category. This case was uploaded via vigiflow under the pharmacovigilance programme of India having report Id 2019-30695.
Authors and Affiliations
Melcy Mary Philip 1*, Kala Kesavan P 1, Jai Prakash 2
Keywords
Related Articles
- EP ID EP690855
- DOI 10.5281/zenodo.4016769
- Views 190
- Downloads 0
Drug Related Problems on Anti-platelets and Anti-coagulants in Stroke
The aim of the research work is to access, evaluate and monitor the drug related problems on antiplatelet and anticoagulants in stroke patients. Antiplatelet agents prevent platelets from dumping and prevent clots from f...
A Review on Potential Drug Delivery System as a Treatment of Intercellular Bacterial Infection
Intracellular bacterial pathogens are hard to treat because of the inability of conventional antimicrobial agents belonging to widely used classes, like aminoglycosides and β-lactams, fluoroquinolones, or macrolides to p...
Metformin related adverse events: A prospective observational study in health care centers of western Odisha
The study was done to explore the management of the patients having diabetes by primary care physicians, and the adverse reactions associated with the dose regimens. A qualitative In-Depth Interview study was conducted a...
Cutaneous Adverse Drug Reactions in a Tertiary Care Hospital: An Observational Study
Cutaneous adverse drug reactions (CADRs) are one of the most common ADRs caused by drugs causing a lot of morbidity and mortality. The overall incidence of CADRs in developed countries is 1-3 %, while that in the develop...
Materiovigilance: Current status in India analogous to its global status
Medical devices are boon to the healthcare system and are available in the market since long ago. More than 500,000 different types of the medical devices are available in the international market. Thus, from the patient...