Toxicological and biological evaluation of broiler-chickens products at farmazyn and tylotsyklinvet application
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2018, Vol 32, Issue
Abstract
Introduction. Currently, in the European Union countries, as well as in Ukraine, the ban on the use of fodder antibiotics and hormonal drugs, as growth stimulators for animals, including broiler chickens, was introduced. It is necessary to investigate the biological value of the broiler chickens’ meat in order to study the quality of this meat and its rational use. The goal of the work is to study the influence of the antibacterial preparations – pharmazin and tilotsiklinvet – on the amino acid composition and toxicity of broiler chickens meat during their use. Materials and methods. For the experiment we formed four groups of one day old broiler chickens of Cobb 500 cross – two control and two experimental (12 broiler chickens in each). Chickens of the first experimental group were given to drink farmazin preparation containing 500 mg per in 1 g of active substance (AS) of tylosin tartrate, and in the second group – tylocyclinvet containing AS tylosin tartrate and doxycycline hyclate of in dose of 100 mg per 1 g in powder form. Antibiotics were given to drink to broiler chickens with preventative purpose at a dose of 1 g per 1 dm3 of water for the first 3 days of life, then on the 28th–29th and 38th–42th days of the experiment. After the antibiotics giving, 6 broiler chickens of each group were slaughtered at the beginning of elimination (in 3 hours) and at the end of the withdrawal period (in 5–8 days) respectively, after the last farmazin and tylocyclinvet usage. Results of research and discussion. It was found that the pharmazin application causes decrease of the essential to nonessensial amino acids rate in femoral and pectoral muscles of broiler chickens by 15.1% and 6.2%, respectively, at the beginning and at the end of the withdrawal period. Use of tilotsiklinvet causes the inverse tendency: the ratio of essential to nonessential amino acids in the studied muscles increases by 25.2% and 6%, respectively. The amino acid, which limits the biological value of the protein – methionine, has been found. The ratio of tryptophan to oxyproline content in the muscles of broiler chickens in experimental groups increased compared to the indicators of control groups, which indicates decrease in the amount of connective tissue, and an increase in the biological value of poultry meat. In addition, the results of the research of the chicken broilers' muscle toxicity, which were given pharmazin and tilotsiklinvet, indicated that all kind of pathological changes in Tetraсhуmena pуriformis culture were detected in experimental groups of broiler chickens except growth retardation. Conclusions and prospects for further research. It was found that the content of essential and nonessential amino acids in the muscles of broiler chickens in experimental groups (that were fed pharmazin and tilotsiklinvet), at the beginning of the withdrawal period exceeds the indicators obtained at the end of the half-withdrawal period. Based on the results of toxicity studies, it was found that poultry meat after pharmazin and tilotsiklinvet application was slightly toxic.
Authors and Affiliations
Inna Zabarna, Natalia Usachenko
Keywords
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- EP ID EP389325
- DOI 10.31073/vet_biotech32(2)-19
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