TOXICOLOGICAL EVALUATION OF A MONOTERPENE ESTER, BORNYL PIPERATE FROM PIPER CHABA ROOT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 12
Abstract
Toxicological evaluation of bornyl piperate, a cytotoxic, antifungal and anti tubercular compound isolated from Piper chaba, was carried out on Swiss albino mice. After administration of the compound, blood and tissue samples of the mice were examined for haematological, biochemical and histopathological assay. A decrease in serum levels of SGPT, SGOT and ALP was observed when two groups of the experimental mice were given doses of 10 and 20 mg/kg of bornylpiperate, respectively, for 14 days. Other parameters such as RBC, WBC and platelet counts were found normal. Microscopic examination of the heart, liver, lung and kidney tissues showed inflammation, sinusoidal congestion and necrosis only at a dose of 20 mg/kg. Thus the results indicate that the bornylpiperate showed moderate toxicity at higher dose in mice.
Authors and Affiliations
Tarannum Naz, Ashik Mosaddik, Md. Haque
Keywords
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- EP ID EP142585
- DOI 10.7897/2230-8407.0512186
- Views 66
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