Toxicological Evaluation of Crude Alkaloid Fraction Isolated From Indian Folklore Plant Telosma Pallida (Roxb) wg Craib Root Using Probit Value Analysis
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2016, Vol 4, Issue 2
Abstract
Present study first time reported the toxicological profile of Telosma pallida (TP) crude alkaloid fraction (CAF) isolated from the root of the climber plant by brine shrimp lethality test (BLT). Telosma pallida is a perennial herb found throughout the Junagadh district and surrounding. Previous studies showed the use of these alkaloids in the inhibition of thymidylate synthetase enzymes and cell growth. Brine shrimp toxicity study was carried out with Artemia salina Leach. In this assay, brine shrimp was hatched in sea salt water and allowed to contact with various concentrations of the crude alkaloid fractions. At 500μg/ml, highest mortality was found 74.44±0.35%whereas in the case of positive control, at the dose of 50μg/ml, 80.00±0.609% mortality was found. LD50 values for CAF and test control was found to be 89.12μg/ml and 12.59μg/ml, respectively. Further in-vitro and in-vivo studies may testify the anticancer potential of this plant.
Authors and Affiliations
Punit R. Bhatt , Kajal B. Pandya , Navin R Sheth
Keywords
Related Articles
- EP ID EP596716
- DOI 10.15415/jptrm.2016.42009
- Views 144
- Downloads 0
Clinical Symptoms and Therapies for Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic form, progressive and immune mediated central nervous system disorder that affects both adults and children. MS is characterized by the development of multiple lesions with the nerve...
Development and Validation of Static HS-GC Method for the Determination and Quantification of Residual Solvents of Bromhexine Hydrochloride (BHX)
The determination of residual solvents in drug substances is the mandatory requirement by various health authorities in the world. There are no analytical methods available in the literature that can simultaneously separ...
Pharmacognostic Standardization of Biophytum Sensitivum Dc
Biophytum sensitivum DC. (Family – Oxalidaceae) is a traditional drug used in treating various ailments especially in mental disorders. The present study was envisaged to establish pharmacognostic standards of the plant...
Toxicological Evaluation of Crude Alkaloid Fraction Isolated From Indian Folklore Plant Telosma Pallida (Roxb) wg Craib Root Using Probit Value Analysis
Present study first time reported the toxicological profile of Telosma pallida (TP) crude alkaloid fraction (CAF) isolated from the root of the climber plant by brine shrimp lethality test (BLT). Telosma pallida is a per...
Assessment for Sporicidal Activity of Two Types of Peroxygen/Silver-Based Disinfectants: A Comparative Study
Numerous cases have been reported globally showing outbreaks, dissemination of infections and/or spoilage of medicinal products, food and other consumables that affects human life and may lead to death in some cases. One...