TOXICOLOGICAL STUDIES OF FICUS VIRENS IN WISTAR ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
The present study was conducted to investigate the toxic effect of oral administration of methanolic leaf extract of Ficus virens in Wistar albino rats.The phytochemical analysis of the F.virens extract was carried out using high performance thin layer chromatography revealed for the presence of flavonoids, bitter principles, coumarins and absence of alkaloids, anthracene derivatives. Acute oral toxicity study (OECD 423) showed no clinical signs of toxicity and mortality even at dose of 2000-5000 mg/kg in 24 h and 14 day observation period. For repeated dose 28-day oral toxicity study (OECD 407) extract was given at dose of 50, 200, and 800 mg/kg and limit dose of 1000mg/kg for 28 days and compared with the control group given with the distilled water. The result showed no significant increase (P>0.05) in biochemical parameters (AST, ALT, BUN and creatinine) and haematological parameters. No significant decrease in feed consumption and body weight gain, also there were no treatment related gross and histopathological changes. In conclusion, methanolic leaf extract of F. virens did not revealed any clinical signs of toxicity and mortality in both acute and repeated dose 28-day oral toxicity study at given dose and duration in Wistar albino rats. LD50 value may be more than 2000 mg/kg, can be classified as category 5 and indicating non-toxic nature of the methanolic leaf extract of Ficus virens.
Authors and Affiliations
Jayashree Pattar, N. B Shridhar, Vijaykumar Matham , K Suhasini, Jayakumar , M. L Satyanarayana
Keywords
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