Traditionally Used Plants with the Inhibitory Effect of Platelet Aggregation
Journal Title: RADS Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 6, Issue 3
Abstract
During hemostasis, after vascular injury and wound healing process, platelets play a very significant role, where the platelets hypersensitivity is also related to the progression or development of various cardiovascular diseases. In this regard, there is a need to find such compounds, which provide more potent and safer activity against platelets with minimum side effects. This review article provided an overview of various medicinal plants having antiplatelet properties or pointed out the constituents associated with the activity, the part used for the isolation of plant constituents, and different pathways which mediate the antiplatelet activity. In this review different classes such as Liliaceae, Zingiberaceae, Rutaceae, Arecaceae and Asteraceae were suggested for their antiplatelet properties to which various medicinal plants belong possessing such properties. Specific bioactive components in different medicinal plants which relate to the antiplatelet properties are flavonoids, polyphenols, terpenoids and glucosides. These substances correct the abnormal state of platelets causing various diseases by changing the signaling pathways such as inhibition of thromboxane production, reduction of PKC activator; reduce the intracellular level of calcium, PAF or collagen receptor antagonist and inhibition of PLC and GPIIb-IIIa activation. It was observed that most of the components in these plants inhibiting the platelet activity by inhibiting ADP, Thromboxane and PAF activity. These investigated mechanisms provided data to develop new formulation in the treatment of thromboembolic disorders by inhibiting the aggregation of platelets.
Authors and Affiliations
Zuneera Akram
Keywords
Related Articles
- EP ID EP605018
- DOI -
- Views 189
- Downloads 0
Research paper Formulation and Evaluation of Sustained Release Matrix Tablets of Furosemide Using Different Polymers
Objective: The aim of the present research study was to develop and evaluate sustained release matrix tablets of 100 mg furosemide using direct compression method. Method: Eighteen formulations were prepared using differ...
Comparative Study of In-vitro Evaluation of Two Quinolone Derivatives by HPLC
Background: Quinolones are the antibacterial agents which vigorously inhibit the DNA synthesis. Pharmacodynamically they are DNA Gyrase inhibitor. Objective: The aim of this study is to compare two quinolone derivatives...
Sonographic Association of Prostate Volume with Post Micturition Residual Volume in Benign Prostate Hyperplasia
Objective: To evaluate the association of prostate volume with post micturition residual urinary volume (PMR) in benign prostate hyperplasia (BPH). Methods: This was cross-sectional analytical study with sample size of...
Pharmaceutical Analysis of Different Brands of Solifenacin Tablets Available in Pakistani Market
Objective: The current study was designed to evaluate and compare the quality and physiochemical characteristics of three different most commonly used brands of Solifenacin (10 mg) tablets available in Karachi, Pakistan....
Traditionally Used Plants with the Inhibitory Effect of Platelet Aggregation
During hemostasis, after vascular injury and wound healing process, platelets play a very significant role, where the platelets hypersensitivity is also related to the progression or development of various cardiovascular...