Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 73, Issue 2
Abstract
<strong>Objective:</strong> To assess the efficacy of tranexamic acid in reduction of blood loss and pervention of postpartum hemorrhage after vaginal delivary. <strong>Methods:</strong> This is a multicentric prospective randomized double blind placebo controlled trial. 200 pregnant women were randomized to receive either 60 mg/kg of tranexamic acid (TA) (n=100) or placebo (n=100) intravenously in the second stage of labour. Postpartum blood loss was collected and measured accurately from placental delivery to 2 hours postpartum and adverse effects of were observed. <strong>Results:</strong> The mean estimated postpartum blood loss was significantly lower in women treated with tranexamic acid compared to women in the placebo group ( 442.50 ± 128.55 versus 555.75 ± 191.88, respectively; p < 0.001), and the proportion of women in the tranexamic acid group who had an estimated blood loss ≥ 500 mL was significantly lower than in the placebo group( 3 [3 %] versus 9 [9%],relative risk [RR]=0.30; 97% confidence interval [CI] 0.11 to 0.78;P<0.05). Maternal and neonatal outcomes did not differ significantly between both groups. <strong>Conclusion:</strong> The addition of tranexamic acid to the active management of third stage of labor after normal vaginal delivery is effective as a prophylaxis against post-partum hemorrhage. It can significantly reduce blood loss during and after delivery. <strong> </strong>
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584455
- DOI 10.12816/ejhm.2018.12737
- Views 107
- Downloads 0
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