TRANSDERMAL MAGNESIUM SPRAYS FOR MYOFASCIAL PAIN RELIEF AND FACILITATION OF AUTONOMOUS TWITCH ELICITATION WITH ELECTRICAL TWITCH-OBTAINING INTRAMUSCULAR STIMULATION (ETOIMS)
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: ETOIMS optimally relieves denervation supersensitivity related myofascial pain when autonomous muscle twitches can be elicited focally or remotely at involved trigger points. Aim: To provide objective evidence that autonomous twitch elicitation with ETOIMS is best facilitated with concomitant transdermal magnesium sulfate (MgSO4) spray rather than magnesium chloride (MgCl) or using only faucet-water. Methods and materials: An 83 year old mildly hypertensive patient with refractory migraine and persistent pain had 3 consecutive ETOIMS therapy trials (N=40/trial) with faucet-water wetted electrodes only or with trans-dermal spray supplementation using MgCl or MgSO4. Pain scores, blood pressure (BP) and pulse/heart-rate were recorded before and immediately after each treatment alongside highest level of clinically elicitable twitch-forces/session and number of muscles with autonomous twitches. For MgSO4 sessions (N=30), the patient also measured onset BP and heart-rate/pulse immediately on sitting down, as well as after sitting for 10 minutes without spray and 10 more minutes with MgSO4 spray applied once to paraspinal and limb muscles. Results: ETOIMS results for eliciting autonomous twitches with MgCl spray were equivalent to using faucet-water. One way ANOVA comparisons showed that using MgSO4 significantly increased number of muscles with autonomous twitches and reduced pain and heart-rate/pulse. Twitch-forces (TWF) between the three groups did not differ. MgSO4 spray alone was also able to reduce the systolic BP within 10 minutes. Conclusions: MgSO4 showed the best capacity to potentiate ETOIMS pain relief effects probably through better skin absorption and vasodilation made possible through skin hydration and iontophoresis effects that enabled autonomous twitching.
Authors and Affiliations
Chu J.
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