TRANSFORMING GROWTH FACTOR BETA OF TESTIS GERMINAL CELL IN GUINEA PIG (CAVIA PORCELLUS) AFTER EXPOSURE TO METHANOL EXTRACT OF THE SEEDS OF BITTER MELON (MOMORDICA CHARANTIA) AND DEPOT MEDROXYPROGESTERONE ACETATE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 12
Abstract
Objective: The discovery of male contraceptive drugs continues to be pursued, due to the very small participation of men associated with the lack of contraceptiveÃptions for men. The combination of methanol extract of bitter melon seed and depot medroxyprogesterone acetate (DMPA) becomes the choice that currently being pursued to be applied to men.Methods: The use of guinea pigs as experimental animals conducted research using experimental methods with complete randomized design. The study was divided into four control groups i.e K0; dimethylsulfoxide (DMSO) for 0 week (4 h),K1; Control group of DMSO for 4 weeks, K2; Control group of DMSO for 8 weeks, K3; Control group of DMSO for 12 weeks, and four treatment groups, i.e: group P0; bitter melon seed extract of 50 mg/100g body weight/day for 0 week (4 h), group P1; Bitter melon seed extract of 50 mg/100g BW/day for 4 weeks+DMPA, group P2; Bitter melon seed extract of 50 mg/100g BW/day for 8 weeks+DMPA, P3 group; Bitter melon seed extract of 50 mg/100g BW/day for 12 weeks+DMPA.Results: There was a significant effect (p<0.05) methanol extract of bitter melon seed to increase the transforming growth factor expression -β expression.Conclusion: The methanol extract of bitter melon seed was able to be candidate for herbal contraception.
Authors and Affiliations
Syafruddin Ilyas, Salomo Hutahaean, Nursal Nursal
Keywords
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- EP ID EP605180
- DOI 10.22159/ajpcr.2018.v11i12.27920
- Views 85
- Downloads 0
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