Transmembrane transporters ABCC – structure, function and role in multidrug resistance of cancer cells
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
Resistance to cytotoxic drugs is a significant problem of systemic treatment of cancers. Apart from drug inactivation, changes in target enzymes and proteins, increased DNA repair and suppression of apoptosis, an important mechanism of resistance is an active drug efflux from cancer cells. Drug efflux across the cell membrane is caused by transport proteins such as ABC proteins (ATP-binding cassette). This review focuses on the ABCC protein subfamily, whose members are responsible for multidrug cross-resistance of cancer cells to cytotoxic agents. The authors discuss the structure of ABCC proteins, their physiological function and diseases provoked by mutations of respective genes, their expression in many different malignancies and its connection with resistance to anticancer drugs, as well as methods of reversion of such resistance.
Authors and Affiliations
Sylwia Dębska, Agata Owecka, Urszula Czernek, Katarzyna Szydłowska-Pazera, Maja Habib, Piotr Potemski
Keywords
Related Articles
- EP ID EP66528
- DOI -
- Views 182
- Downloads 0
Kliniczne znaczenie receptora chemokinowego CXCR4
Czynnik pochodzenia stromalnego 1 (stromal cell-derived factor-1 – SDF-1/CXCL12) uruchamia szlaki przekazywania sygnału kluczowe dla mobilizacji, migracji, proliferacji oraz przeżycia wielu typów komórek, ekspresjonujący...
Spożycie ryb a ryzyko wystąpienia raka prostaty
W pracy omówiono zależności między spożyciem ryb, jako surowców bogatych w wielonienasycone długołańcuchowe kwasy tłuszczowe (LC PUFA) omega-3, a ryzykiem wystąpienia nowotworu stercza. Wiele badań naukowych potwierdza k...
Selected aspects of Clostridium difficile infection
Clostridium difficile pathogen is a cause of the most frequent nosocomial infection, which is antibiotic-associated diarrhea. Antibiotic treatment causes disruption of the microbiome balance, which makes the gut a friend...
Mechanisms of endocytosis utilized by viruses during infection
Viruses, despite being relatively simple in structure and composition, have evolved a broad spectrum of mechanisms to exploit the host cell. To initiate effective infection, viruses or viral genomes have to enter cells....
The influence of air pollution on human reproduction
Air pollution is the main reason for global environmental hazards and human population. It is caused by different chemical compounds emitted by industry, vehicles and households. When inhaled with air, such substances ge...