Transmembrane transporters ABCC – structure, function and role in multidrug resistance of cancer cells
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
Resistance to cytotoxic drugs is a significant problem of systemic treatment of cancers. Apart from drug inactivation, changes in target enzymes and proteins, increased DNA repair and suppression of apoptosis, an important mechanism of resistance is an active drug efflux from cancer cells. Drug efflux across the cell membrane is caused by transport proteins such as ABC proteins (ATP-binding cassette). This review focuses on the ABCC protein subfamily, whose members are responsible for multidrug cross-resistance of cancer cells to cytotoxic agents. The authors discuss the structure of ABCC proteins, their physiological function and diseases provoked by mutations of respective genes, their expression in many different malignancies and its connection with resistance to anticancer drugs, as well as methods of reversion of such resistance.
Authors and Affiliations
Sylwia Dębska, Agata Owecka, Urszula Czernek, Katarzyna Szydłowska-Pazera, Maja Habib, Piotr Potemski
Keywords
Related Articles
- EP ID EP66528
- DOI -
- Views 176
- Downloads 0
Probiotic bacteria in the human gastrointestinal tract as a factor stimulating the immune system
The role of bacterial microflora of the human digestive tract in supporting the protection of the organism against food-borne pathogens and antigens is described. The effect of bacterial microflora on the immune system o...
Yeast as a model for studying neurodegeneration
At the level of genetics and physiology the yeast Saccharomyces cerevisiae is are the best characterized eukaryotic cells. The yeast cells can be used as a model to study the mechanisms involved in human disease. Yeast...
The participation of outer membrane proteins in the bacterial sensitivity to nanosilver
The presented study is to analyze the participation of outer membrane proteins of Gram- negative bacteria in sensitivity to silver nanomaterials. The mechanism of interaction of silver with the bacterial cell is best des...
Increased percentage of CD8+CD28– suppressor lymphocytes in peripheral blood and skin infiltrates correlates with advanced disease in patients with cutaneous T-cell lymphomas
Introduction: T cells with the CD8+CD28– phenotype are CD8+ lymphocytes with regulatory function. Their increased numbers were observed in infections, autoimmune and neoplastic diseases, and in elderly healthy individual...
Activity of N-acetyl-β-hexosaminidase and its isoenzymes A and B in cancer
There were approximately 93,060 deaths from cancers in Poland in 2008, and about 105,000 are predicted for the year 2025. Early detection of cancer is a major problem throughout the world, which is why many researchers a...