Trauma Related ARDS Biomarkers: Rapid Review
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Introduction: The major reasons behind death after severe traumas are multiple organ dysfunction syndrome (MODS) and systemic inflammatory response syndrome (SIRS). Acute respiratory distress syndrome (ARDS) is one complication of MODS. Biomarkers are important in the prediction of ARDS, including early detection, risk of adverse outcomes and prognosis. Objective: The aim of this review is to collect ARDS biomarkers among traumatic patients. Methodology: A web based search was used and online data bases from PUBMED and MEDLINE were searched. Studies from 1999 to 2018 were included. A total of 50 studies fulfilled the review parameters and were included. Results: When trauma occurs, the level of biomarkers rises within first 24 to 48 hours before it returns to normal. For the diagnosis of ARDS in traumatic patients, multiple biomarkers are used. Examples are von Willebrand factor (vWF), angiopoietin-2 (Ang- 2), Krebs von den Lungen-6 (KL-6), soluble receptor for advanced glycation end products (RAGE), tumor necrosis factor-alpha (TNF- α), interleukin-1 beta (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), Procollagen III peptide (PCPIII) and macrophage migration inhibitory factor (MMIF). Presence of IL-1β, IL-4, KL-6 and angiopoietin-2 increases the probability of mortality. Conclusion: Initial increase in the level of biomarkers is predictive of the disease severity as they are the early diagnostic biomarkers for ARDS. Therefore, early measurement of these biochemical markers could be incorporated into trauma management protocols along with Injury Severity Score and Revised Trauma Score.
Authors and Affiliations
Saud Maged Alotaibi, Mohammed Maged Alotaibi, Abdulhamid Ayman Kabli
Keywords
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- EP ID EP540063
- DOI 10.21276/ijmrp.2018.4.2.066
- Views 73
- Downloads 0
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