Treating Painful Diabetic Peripheral Neuropathy
Journal Title: Scholars Bulletin - Year 2017, Vol 3, Issue 6
Abstract
Abstract:Diabetic neuropathy (DN) is a common complication of both type-1 and type-2 diabetes, which affects over 90% of the diabetic patients. The distal symmetrical polyneuropathy (DSPN) is the commonest clinical form of diabetic neuropathy, affecting more than 90% of the patients. Painful diabetic neuropathy (PDN) is one of the most common of all type of the long-term complication of diabetes, affecting up to 50% of patients. The most common sites of pain are in the periphery involving the feet, toes, and hands.DNP continues to represent a therapeutic challenge as its pathophysiology is not yet fully understood and pain relief is still unsatisfactory. Clinical guidelines recommend pain relief in PDN through the use of antidepressants such as amitriptyline and duloxetine, the γ-aminobutyric acid analogues gabapentin and pregabalin, opioids and topical agents such as capsaicin. Of these medications, duloxetine and pregabalin were approved by the US Food and Drug Administration (FDA) in 2004 and tapentadol extended release was approved in 2012 for the treatment of PDN. This review does not widely discuss all possible treatments for painful neuropathy; however it provides a systematic approach designed to guide clinicians in tailoring therapies to the individual patient. Keywords: diabetic neuropathy, painful neuropathy, pregabalin and duloxetine.
Authors and Affiliations
Umakanth M
Keywords
Related Articles
- EP ID EP382285
- DOI -
- Views 134
- Downloads 0
Characteristics of Micro-Pore Structure of Tight Sandstone Reservoir: A Case Study from ImsarSag Tight Oil Reservoirs
Abstract: Jimusaer sag Lucaogou Formation tight oil reservoir lithology is changeable, diverse mineral elements and clastic rock and carbonate rock of the transitional rocks. Dense oil in the region to the source of vari...
Application of Structure Fine Interpretation Technology
Abstract:Structural conditions as one of the elements of oil and gas accumulation, attracted widespread attention in the oil and gas field exploration and development. Typically, the lower the accuracy of regional explor...
Influence of Enforcement Strategies on Tax Compliance in the Informal Sector in Kenya: Survey of Nyeri Town
Abstract:Tax non-compliance reduces tax collection and the tax performance within a country. The Kenyan government has implemented various strategies to bring businesses in the informal sector into the tax bracket though...
An Appraisal of Libraries, Staffing and Information Resources in Bauchi State of Nigeria
Abstract:The library is indispensable in both formal & informal ways of knowledge seeking. This paper explored what a library is and its role in education and human development in general. It investigates the availabilit...
The Effect of Leadership, Motivation, and Compensation on Employee Performance (Case Study at XYZ Company)
Abstract:This study aims to examine and analyze the influence of motivational leadership and compensation on employee performance of PT XYZ. The sampling method used is a saturated sample. The population is 47 employees...