Treatment of Helicobacter pylori-Associated Diseases in Ukraine. The Place of Colloidal Bismuth Subcitrate in the Combination Therapy of These Patients
Journal Title: Гастроентерологія - Year 2015, Vol 4, Issue 58
Abstract
The article considers one of the most topical issues of modern gastroenterology — the treatment of Helicobacter pylori (Hp) infection. It was stressed that eradication therapy is currently determined by Maastricht IV consensus report, and according to the current standards, the first-line therapy should be based on national or regional features of pathogen susceptibility to major antibacterial agents. In case of multiple resistance of Hp, regimens containing fluoroquinolones are used in many countries at the first stage. In countries with a high prevalence of tuberculosis infection, which include Ukraine, to slow the development of mycobacterial resistance, it is necessary to minimize the use of these fluoroquinolones for the treatment of other infections. Therefore, regimens of Hp eradication with the inclusion of fluoroquinolones in our country should be used only after ineffectiveness of the initial treatment at the second stage. Today, bismuth-containing quadruple regimens are used most often. The advantages of using bismuth preparations in antihelicobacter therapy are actively studied and proved in clinical trials. In Ukraine, bismuth-containing regimens with application of colloidal bismuth subcitrate are being used as second-line therapy. This article presents the results of the study on the efficacy of the modified quadruple therapy (proton pump inhibitors combined with furazolidone, amoxicillin and colloidal bismuth subcitrate (De-Nol)) when Hp infection is not eliminated after standard triple therapy. Attention is paid to the differences of treatment regimens taking into account regional features of Hp resistance.
Authors and Affiliations
A. E. Dorofeiev, M. M. Rudenko, S. M. Tkach, A. V. Sybiliov
Keywords
Related Articles
- EP ID EP214217
- DOI -
- Views 84
- Downloads 0
Features of Histological Structure of the Esophagus and Stomach in Inflammatory and Erosive and Ulcerative Diseases of the Upper Gastrointestinal Tract, Associated with Mucosal Candidiasis
The study involved 84 patients with inflammatory and erosive and ulcerative diseases of esophagogastricarea, 72 of them — with Candida infection. It is found that typical histological features are dyskeratosis of esophag...
The Role of Phosphatidylcholin for Correction of Hepatobiliary Disorders at Enteropathy
The article considers the hepatobiliary disorders at enteropathy, therapeutic strategy for hepatobiliary disorders in enteripathy. There have been presented the results of our own investigations of the effectiveness of E...
First district sanitary doctor of Katerynoslav
The life and professional activity of Vasyl Tymofiiovych Skrylnikov — a famous doctor-hygienist, scientist, and public figure have been represented. V.T. Skrylnikov contributed to the development of sanitary-prophylaxis...
Cytokine Status in Children with Chronic Gastroduodenal Pathology
Actuality. Diseases of the stomach and duodenum in children tend to continual growth, and the pathology itself is characterized by a group of features that are absent in adults. Aim: to identify the features of blood ser...
Short-chain fatty acids: the role in the development of irritable bowel syndrome
The article deals with the concepts of irritable bowel syndrome. A brief analysis of probable factors of irritable bowel syndrome development was performed. The role of intestinal microflora and the contribution of short...