Triple Therapy with Doxorubicin, Imatinib and Tamoxifen in Recurrence Desmoids Tumor Associated with Pregnancy: Case Report and Literature Review
Journal Title: International Journal of Cancer Management - Year 2017, Vol 10, Issue 1
Abstract
Introduction: Desmoid tumors, also known as aggressive fibromatosis, grow slowly but are locally aggressive. The therapy strategy consists of surgery, and radiation. Systemic therapy with non-steroidal anti-inflammatory drugs, antiestrogen compounds, cytotoxic chemotherapy and protein kinase inhibitors are recommended for recurrence, unresectable, advanced disease and failure to response to primary treatment. Case Presentation: We report on a 35-year-old female patient with advanced fibromatosis of the soft tissue of neck who has been treated with triple therapy including 8 cycles of Doxorubicin, Tamoxifen daily, and Imatinib daily. Tumor response was evaluated clinically and by enhanced CT SCAN imaging. Conclusions: 90% reduction in tumor size occurred after 6 months of treatment. The response continued and after 8 courses of doxorobicine treatment switched to triple therapy with imatinib , tamoifen and celexocib
Authors and Affiliations
Keywords
Related Articles
- EP ID EP237267
- DOI -
- Views 73
- Downloads 0
Promoter Hypermethylation Analysis of the Tumor Suppressor Genes RASSF1A and RASSF2A in Iranian Endometrial Carcinoma Patients
Introduction The endometrial cancer (EC) is the seventh most common malignancies worldwide among females with good prognosis in early stages of the disease. The CpG Island in the...
Symptomatic Occlusion of Internal Carotid Artery Caused by Pituitary Macro Adenoma Among the Patients Without Apoplectic Signs; Case Report and Review of the Literature
Introduction Pituitary adenoma producing symptomatic carotid compression of the internal carotid artery without any apoplexy sign would be extremely rare and there was only one re...
Simultaneous Occurrence of B-Cell Lymphocytic Leukemia and Acute Myeloid Leukemia in an Elderly Female Patient
Introduction The coexistence of B-cell chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) in the same patient is rare. The aim of this study is to report of simul...
Co-Administration of Anti-Angiogenic Peptide and DNA Vaccine in Cervical Cancer Tumor Model
Background Cervical cancer is one of the main causes of women’s death in the world. Human papilloma virus (HPV) types 16 and 18 have been known as a cause of more than 2/3 of cerv...
Comparison of Three Clinical Models for Estimating the Risk of Endometrial Cancer in Post-Menopausal Women with Abnormal Vaginal Bleeding
Background: Given the prevalence of abnormal post-menopausal bleeding and the importance of its early examination for ensuring the timely diagnosis of any malignancies, the present study was conducted to investigate uter...