Triple Therapy with Doxorubicin, Imatinib and Tamoxifen in Recurrence Desmoids Tumor Associated with Pregnancy: Case Report and Literature Review
Journal Title: International Journal of Cancer Management - Year 2017, Vol 10, Issue 1
Abstract
Introduction: Desmoid tumors, also known as aggressive fibromatosis, grow slowly but are locally aggressive. The therapy strategy consists of surgery, and radiation. Systemic therapy with non-steroidal anti-inflammatory drugs, antiestrogen compounds, cytotoxic chemotherapy and protein kinase inhibitors are recommended for recurrence, unresectable, advanced disease and failure to response to primary treatment. Case Presentation: We report on a 35-year-old female patient with advanced fibromatosis of the soft tissue of neck who has been treated with triple therapy including 8 cycles of Doxorubicin, Tamoxifen daily, and Imatinib daily. Tumor response was evaluated clinically and by enhanced CT SCAN imaging. Conclusions: 90% reduction in tumor size occurred after 6 months of treatment. The response continued and after 8 courses of doxorobicine treatment switched to triple therapy with imatinib , tamoifen and celexocib
Two Side Effects of Sutent Therapy in Renal Cell Carcinoma: A Case Report
Introduction Renal cell carcinoma (RCC) has known as the most frequent urological malignancy among adults, which occured mostly among male patients. Sunitinib malate (SUTENT<sup>®...
Epidemiology of Nervous System Tumors According to WHO 2007 Classification: A Report of 1,164 Cases from a Single Hospital
Background: The central nervous system (CNS) belongs to heterogeneous group of glial and non-glial brain tumors. Increase in the frequency of brain and CNS tumors in Iran have been a cause for debate and concern. Object...
Evaluation of Anti-Melanogenic and Cytotoxic Activities of <i>Phlomis caucasica</i> on Human Melanoma SKMEL-3 Cells
Background Under normal physiological condition, melanosomal melanin acts as a natural UV photoprotective filter. However, after long exposure to UV radiation, melanin has shown t...
Application of Cold Atmospheric Plasma (CAP) in Cancer Therapy: A Review
Background Recently the use of cold atmospheric plasma (CAP) for the treatment of cancers called “Plasma Oncology” has gained promising results. The developments have raised the h...
Topical Calcineurin Inhibitors and Malignancy Risk
Context The approval of topical calcineurin inhibitors (TCIs) has been a significant breakthrough for the treatment of atopic dermatitis due to much lower systemic absorption and...