Tualang Honey Ameliorates Hypoxia-induced Memory Deficits by Reducing Neuronal Damage in the Hippocampus of Adult Male Sprague Dawley Rats
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 5
Abstract
Objectives: A growing body of evidence indicates that hypoxia exposure causes learning and memory deficits. An effective natural therapeutic approach has, however, not been explored widely. Our previous studies found that Tualang honey administration protected learning and memory functions in ovariectomized rats. Therefore, the present study investigated its efficacy in ameliorating hypoxia-induced memory deficits in adult male Sprague Dawley rats. Materials and Methods: The rats were divided into four groups: i) Normoxia treated with sucrose (n=12), ii) Normoxia treated with Tualang honey (n=12), iii) Hypoxia treated with sucrose (n=12), and iv) Hypoxia treated with Tualang honey (n=12). Tualang honey (0.2 g/kg/BW) and sucrose (1 mL of 7.9%) supplementations were administered orally to the rats daily for 14 days. Then the hypoxia groups were exposed to hypoxia (~11%) for 7 days, while the normoxia groups were kept in normal conditions. Following exposure to hypoxia, the rats’ memories were analyzed using a novel object recognition task and T-maze test. Results: The data revealed that rats exposed to hypoxia showed significant impairment in short-term memory (STM), spatial memory (p<0.01), and long-term memory (LTM) when compared to the normoxia group. Hypoxia rats treated with Tualang honey showed significant improvement in STM, LTM, and spatial memory (p<0.05) compared with those treated with sucrose (p<0.05). Tualang honey also reduced neuronal damage in the hippocampus of adult male Sprague Dawley rats exposed to hypoxia. Conclusion: It is suggested that Tualang honey pretreatment has protective effects against hypoxia-induced memory deficits, possibly through its antioxidant contents.
Authors and Affiliations
Entesar Yaseen Abdo QAID, Rahimah ZAKARIA, Nurul Aiman MOHD YUSOF, Shaida Fariza SULAIMAN, Nazlahshaniza SHAFIN, Zahiruddin OTHMAN, Asma Hayati AHMAD, Che Badariah ABD AZIZ, Sangu MUTHURAJU
Keywords
Related Articles
- EP ID EP690000
- DOI 10.4274/tjps.galenos.2019.32704
- Views 122
- Downloads 0
Effect of Panax ginseng on Carbamazepine Pharmacokinetics in Rabbits
Objectives: Carbamazepine (CBZ) is a well-known drug prescribed to treat epilepsy and the preferred drug for trigeminal neuralgia. This study was conducted to investigate the effect of Panax ginseng extract (PGE) on the...
Development of a Structured Communication and Counseling Skills Course for Pharmacy Students: A Simulation-based Approach
Objectives: We aimed to develop a structured communication and counseling education program to improve pharmacy students’ skills. Then, we objectively assessed this program by using simulated patients. The program aims t...
Anti-inflammatory and Analgesic Effects of Limnophila repens (Benth.)
Objectives: The analgesic and anti-inflammatory effects of methanolic extract of Limnophila repens (MELR) were assessed at 200 and 400 mg/kg. Materials and Methods: In carrageenan-mediated paw edema, the anti-inflammato...
Quantitative Structure–Activity Relationship Analysis of Selective Rho Kinase Inhibitors as Neuro-regenerator Agents
Objectives: To understand the role of Rho (serine/threonine) kinases in the treatment of neurological segments, attempts have been made to find potent inhibitors of Rho enzyme by a 2D quantitative structure–activity rela...
In Vitro Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profiles of Moltkia aurea and Moltkia coerulea
Objectives: In Turkey, the genus Moltkia Lehm. is represented by two species, namely Moltkia aurea Boiss. and M. coerulea (Willd.) Lehm., which are used as both food and for medicinal purposes. This study aimed to evalua...