Tuberculosis 2020
Journal Title: Biomedicine & Prevention - Year 2016, Vol 2016, Issue 0
Abstract
Tuberculosis (TB) still causes an out-sized burden of morbidity and mortality, remaining one of the human infections with the highest prevalence worldwide. This is calling for efficient measures of prevention and control, in particular for an efficient preventive vaccine and the rapid identification of subjects with active-TB capable to transmit the bacillus. However, the attempts to study new vaccines have been only partially successful or even completely unsuccessful. Similarly, current diagnostic tests are affected by a large number of limitations due to reduced or suboptimal sensitivity, time to results, or instrumental needs and costs. To identify novel vaccine targets and develop efficient diagnostic tools, research has to focus on the understanding the mutual interaction of the MTB and host studying the different infectioun stages. This approach can bring both to novel vaccine targets and biomarkers for the diagnosis and monitoring vaccine effectiveness.
Authors and Affiliations
Massimo Amicosante
Keywords
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- DOI 10.19252/000000026
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