Type 2 Diabetes (T2D) and Arsenic at low concentrations: are there any real associations? A systematic review.
Journal Title: Biomedicine & Prevention - Year 2016, Vol 2016, Issue 1
Abstract
Incidence and prevalence of Type 2 diabetes (T2D) are rapidly increasing worldwide, characterizing a true epidemic. Although much is already known about this disease, classical theories on its pathogenesis don’t fully explain the present situation. Current scientific research has focused on environmental factors to fill these knowledge gaps. Long-life exposure to metals, in particular Arsenic, has been identified as a risk factor of T2D. If the association is statistically significant at high levels of exposure, long-term effects of low to moderate Arsenic concentrations remain substantially controversial. The purpose of this systematic review is to shed light on this grey area, focusing on the current knowledge of exposures lower than 100μg/L. The vast majority of reports in the medical literature, published from 2005 to 2016, show a similar trend: they identify a significant association between type 2 Diabetes and Arsenic exposure. Some controversial points still remain, making further research necessary: the poor robustness of most studies, as well as the existence of complex factors that could modify the effect of exposure to arsenic, and the existence of distinct subpopulations, not taken into consideration as heterogeneous in the medical literature. In summary, all these factors should be considered before designing future studies.
Authors and Affiliations
Sandro Mancinelli, Patrizia De Filippis, Alessandra Messina, Maria Spoto, Stefano Orlando, Laura Morciano, Leonardo Palombi, Francesca Lucaroni
Keywords
Related Articles
- EP ID EP334775
- DOI 10.19252/000000030
- Views 185
- Downloads 0
Laboratory and diagnostic test mobile systems: critical issues and perspectives in the field of major disasters
Health Units of the Military Corps of Italian Red Cross (CRI) have proven to be usefully applied in both pace mission (i.e., Operation Ancient Babylon, IRAQ; 2005) and civil (i.e., EUNAVFOR MED Operation; in progress) sc...
A technical proposal for active sensing monitoring activities in the area of Viggiano (south of Italy) and in rural and urban areas: LIDAR/DIAL techniques to detect the presence of pollutants and to control biomass combustion products like CO or PM10
In this work the authors propose a technical solution for active sensing monitoring in the area of Viggiano and, in general, in urban and rural areas that can be affected by the t diffusion of pollutants or by the disp...
In vitro experimental models to study the efficiency of the placental barrier for environmental toxicants: tumor cell lines versus trophoblast primary cells.
Mammalian development is characterized by an evolutionary innovation represented by the trophoblast, which contributes to the formation of the placenta, a transient organ regulating exchange of nutrients, gases and waste...
The continuing struggle against lung cancer epidemic. Focusing on early stage diagnosis, minimally invasive treatment strategies and effective prevention.
Lung cancer has become among the most deadly tumors in men and women with a mortality rate exceeding that of the other three most common tumors combined. Over 50% of patients diagnosed with lung cancer die within one ye...
Determination of white blood cells in blood components. Experience of Tor Vergata transfusion service.
ABSTRACT. Background. The number of White Blood Cells (WBCs) that are contained in blood components is very important to guarantee a safe transfusion therapy (1, 3, 4). Objective. Our goal is to show that our Service is...