Upregulation of Peripheral Blood Levels of Immune-Regulatory Interleukin-10 Cytokine in Human Immunodeficiency Virus-infected Compared to Non-infected Pregnant Women
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
Alterations in the cytokine status have been suggested to be at least partly responsible for the immune tolerance during pregnancy. Indeed, interleukin-10 (IL-10) cytokine is known to control inflammationinduced pathologies of pregnancy. The current study was set to investigate if HIV infection influences the production of IL-10 cytokine during pregnancy in adult asymptomatic HIV-infected pregnant women (n=44) and antiretroviral-naïve at enrolment as compared to controls (HIV non-infected pregnant women, n=44). Quantitative analysis of the IL-10 cytokines was done using Cytometry Bead Array Technology. Data analysis was performed using STATA version 13. P-value ≤0.05 was considered statistically significant. Results revealed differences in the mean of IL-10 cytokine levels between the HIV-positive and the HIVnegative participants over time across trimesters; trimester one 1.5 [(95% CI: 0.4, 2.5), P=0.008], second trimester 1.0 [(95% CI: 0.2, 1.9), P=0.019], and third trimester 1.2 [(95% CI: 0.3, 2.1), P=0.009]. These results demonstrates that, HIV infection favor the up regulation of IL-10 cytokine production in pregnancy. This upregulation of IL-10 may control inflammation-induced pathologies due to HIV during pregnancy. Further insight into the complexity of IL-10 cytokine in both HIV infections and pregnancy is greatly recommended to enable novel development of therapeutic strategies using this cytokine and targeting HIVinfected pregnant women
Authors and Affiliations
Stanslaus K. Musyoki
Keywords
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