Uric Acid Levels in Pregnancy Induced Hypertension (PIH) in Relation to Maternal and Perinatal Outcomes
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 2
Abstract
Background: Preeclampsia is one of the common conditions of unknown etiology which increases the risk of maternal and perinatal morbidity and mortality. According to some studies, serum uric acid lacks sensitivity and specificity as a diagnostic toolwhereas another group of the researchers indicated uricemia as a predictor of preeclampsia in pregnant ladies. Objective: The present study was designed to assess whether serum uric acid can be used as a biochemical indicator or not, in pregnancy induced hypertensive (PIH) patients. Study period & Method: Total number of 98 PIH patients admitted in GMERS Medical College, Dharpur, from Dec 2013 to Feb 2015 were included in this study and 60 normal healthy pregnant ladies served as control. Serum uric acid levels were estimated using modified Trinder's test. Results: Out of the 98 cases mild preeclamspsia was 60(61.2±%), severe Preeclampsia 24 (24.5%) and eclampsia 14(14.3%). Serum Uric acid levels significantly increased with the severity of PIH, normal pregnant women (4.58±0.37), mild preeclampsia (5.32+0.40), severe preeclampsia (6.29±0.57) and eclamspsia (7.88±1.26). Out of these women with uric acid levels more than 5.5mg/dl was seen in 28(46.6%) mild preeclampsia, 19(79.2%) severe preeclampsia and 12 (85.7%) eclampsia. Maternal mortality was observed in 05(5.1%)PIH cases and out this 04(80) had uric acid level > 5.5mg/dl. Perinatal mortality was observed in 25 (25.1%) cases, out of these 19(76%) were stillbirths and 06(24%) were neonatal deaths. Out of the 25 perinatal deaths 18(72%) had uric acid level >5.5mg/dl. Conclusion: Serum uric acid level could be used as a biochemical indicator of preeclampsia/eclampsia and its complications.
Authors and Affiliations
Liggy Andrew, Nikunj Patel
Keywords
Related Articles
- EP ID EP242441
- DOI -
- Views 58
- Downloads 0
Homocysteine, folate and vitamin b12 status in patients with coronary artery disease in young age
Introduction: Rising incidence of coronary artery disease in India which is rather common causes of morbidity and mortality is not good news. Even by conservative estimate Indian spending an amount that’s nearly 40% enti...
Study of emergency laboratory parameters in acute oraganophosphorus poisoning in a rural population- retrospective study
Introduction Organophosphorus poisoning OPP is one of the common medical emergencies among rural population in India due to suicide attempts The purpose of this study was to investigate the relationship between the initi...
Serum ferritin in pre-diabetes & diabetes mellitus type 2 and its relationship with glycemic status
Introduction: Emerging scientific evidence suggests an increased prevalence of elevated serum ferritin levels in diabetes mellitus type 2. Serum ferritin, being a reliable marker of body iron stores, have been related to...
Levels of serum Gamma Glutamyl Transferase (GGT), high sensitivity C-Reactive Protein (hsCRP) in Myocardial Infarction (MI)-A case control study
Objectives: Acute myocardial infarction (AMI) is a major public health problem among non-communicable diseases in developing countries. Inflammation plays very important role in AMI. Gamma Glutamyl Transfersae (GGT) has...
Diabetes Accelerates Age- Related Lipid Profile Disturbances in Cardiovascular Complications
Cardio Vascular Complications (CVC) are predominant problems both in ageing and diabetes. The present study focuses on the effect of human ageing and diabetes, with special reference to serum lipid profile levels during...