Urinary Cystatin C as an Early Biomarker of Acute Kidney Injury in Critically ill Patient
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
Introduction: Acute kidney injury is associated with high mortality in critically ill patients. We usually measure serum creatinine to detect AKI, but it is a poor predictor of accuracy particularly in the early stages of AKI(1) . We studied the utility of urinary cystatin C and its significance in AKI. Materials and Methods: This prospective observational study was done in 83 critically ill patients admitted in ICU. Serum creatinine was done on day 1 and day 3 which was compared with Urinary Cystatin C done on day 1. Results: Out of the 83 patients, 36 (43.3%;) developed AKI. Serum creatinine on day 1 and day 3 were compared with urinary cystatin C done on day 1. We observed that in the AKI group there was significant elevation of urinary cystatin C (15% (p=0.001)). On contrary in the non AKI group there was a marginal level of increase in urinary cystatin C. As the urinary cystatin C is the early excretory product it can be used as an early biomarker of AKI. Conclusions: We found that the urinary cystatin C levels were significantly elevated in AKI groups when compared with the creatinine levels. Hence we suggest that urinary cystatin C is a significant early biomarker for AKI. Moreover, further studies are warranted with large number of sample size with multicentric population to confirm these results
Authors and Affiliations
Dr Karthik . B
Keywords
Related Articles
- EP ID EP515573
- DOI -
- Views 64
- Downloads 0
Perinatal Outcome in Twin Pregnancy
Background: Multiple pregnancy poses definite risks not only to the mother, but also to the fetuses. Despite improvement in obstetric and neonatal care, risk to the new born remains at least 3 times more than that of sin...
Descriptive Epidemiology and Complications of Haemophilia in Assiut, Egypt
Background: Haemophilia is a group of rare congenital disorders of blood where there’s a defect in mechanism of clotting due to deficiency in factor VIII (Haemophilia A) or factor IX (Haemophilia B). It’s inherited as xl...
Comorbid Anxiety and Depression in Chronic Daily Head Ache Patients
Background: Patients with Chronic daily headache (CDH) have high frequencies of psychiatric comorbidities such as depression and anxiety which play a significant role in the development of drug resistance and chronicisat...
The effect of single dose of preoperative dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study
Objective: To study the efficacy of single dose of preoperative dexamethasone in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Materials and Methods: 110 patient...
Predictors of Admission of Patients with Bronchiolitis to the Intensive Care Unit (ICU)
Background Bronchiolitis is a lower respiratory tract infection that occurs in children younger than two years old. It is usually caused by a virus; Bronchiolitis is a common cause of illness and is the leading cause of...