Urtica dioica attenuate effect of Doxorobicinâ€Induced changes on sperm parameters in the mice
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 11
Abstract
Doxorubicin (DXR) is used as an antitumor agent for the treatment of human neoplasm. The use of DXR has adverse effect on reproductive system including testicular toxicity and alteration in semen quality. The aim of this study was to evaluate the protective effects of Urtica dioica against Doxorobicinâ€Induced changes on sperm parameters. 24 male mice were randomly divided into 4 groups. Control group received normal saline solution throughout the course of the study. Urtica dioica (UD) control group, received UD (100 mg/kg body weight) thrice in a week and DOX (3 mg/kg body weight) once in a week injected intraperitoneally in Doxorubicin (DXR) control group and Urtica dioica- Doxorubicin (UD-DXR) group, received Urtica dioica (100 mg/kg body weight) three times in a week and DOX (3 mg/kg body weight) once in a week through the route for a period of 2 weeks. At the end of experimental period, all animal were sacrificed by cervical dislocation, their epididymes were removed and sperm analysis were done. In mice with DXR administration, epididymal sperm motility, progressive motility, sperm count and viability significantly decrease while sperm cells with abnormal morphology significantly increase when compared with control groups. Co-treatment with UD attenuate toxicity effect of DXR and improve sperm parameters. Results of our study showed that UD diminished DXR-induced testicular toxicity and improve semen parameters, thus suggesting its co-administration as a protective agent during doxorubicin treatment. Further studies should be aimed to determine protective effect of UD against chemotherapeutic agents such as DXR.
Authors and Affiliations
Zahra Baninameh| Sina Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Milad Moloudizargari| Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Hojjat Ghasemnejad Berenji| Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Sedighe RezaieChamani| Department of Midwifery, Faculty of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran, Vajihe Hassanzadeh| Food and Cosmetic Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, Margherita Ferrante| Environmental and Food Hygiene Laboratories (LIAA), ‘G.F. Ingrassia’ Department, Hygiene and Public Health, University of Catania, Catania, Italy, Shokoofe Azarbahra| Student's Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran, Heidar Heidari Khoei| Student Research Committee, Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Corresponding Email: heidari.khoei@gmail.com
Keywords
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