Use of endophytic fungi in the Taxol anticancer drug production
Journal Title: Biotecnología Vegetal - Year 2014, Vol 14, Issue 1
Abstract
Taxol is a drug used in the chemotherapy of breast, lung, ovarian, prostate, liver cancers, and in the treatment of rheumatoid arthritis. Taxol is obtained from Taxus spp. trees. It is found in low concentrations in the bark, needles and roots. The production is obtained by total chemical synthesis, but the process is very costly. The semi-synthesis is obtained from precursors like 10-diacetilbaccatina and baccatin III but has low production. On the other hand, the processes of in vitro culture of callus and cells are seen as a good strategy but in low yield. Therefore, it is urgent to find alternatives for the production of this drug due to the growing demand of Taxol and plant resource scarcity. The most promising way to large scale production of taxol is using in vitro fungi fermentation systems. The aim of this study was to present a review of the updated information in the scientific literature about the use of endophytic fungi in the production of this anticancer compound. We includes the definition of taxoids, the specific mechanism of biological action of Taxol on cancer cells, the enzyme involved in the biosynthesis of Taxol, quantitative methods for detection of taxol from fungi culture and the biotechnological alternative for Taxol production by bioavailability of endophytes of great biological importance from Taxus spp.
Authors and Affiliations
Hebert Jair Barrales-Cureño , Raqueline de la Rosa Montoya
Keywords
Related Articles
- EP ID EP683551
- DOI -
- Views 130
- Downloads 0
An alternative to estimate the retention of atmospheric carbon by Bambusa vulgaris var. Schrad vulgaris. ex J.C. Wendl.
The estimation of atmospheric carbon sequestration by a woody plant has two alternatives for implementation: by identifying the average annual increase in volume or by determining the appropriate method for calculating...
In vitro response differentiation of Phaseolus vulgaris cv. ‘ICA Pijao’ and cv. ‘Tío Canela- 75’ to high temperatures
To develop an in vitro selection protocol, it is necessary to differentiate between tolerant and susceptible cultivars to the studied factor. The present work was carried out with the objective of selecting the tempera...
Effect of desiccation on plantain cv. ‘FHIA-21’ (Musa AAAB) somatic embryos germination
The aspects related to the development of somatic embryo maturation, germination and conversion in plants are necessary for effective mass propagation of bananas and plantains by somatic embryogenesis. For this reason,...
Effect of the cytokinins combination on adventitious buds formation in banana cv. ‘Gros Michel’ (Musa AAA)
Cytokinins are used for adventitious buds formation but high concentrations may have negative effects on plant regeneration. The aim of the present investigation was to determine the effect of different combinations of c...
Use of mutagenesis to improve stem thickness of sugarcane somaclone IBP 89-169
The present work was realized with the aim to improve the somaclon IBP 89-169 selected as highly resistant to the smut of the sugarcane (Ustilago scitaminea Syd) and procedent of the variety Ja 60-5, but imposibilited t...