Use of Intravenous Sulprostone for the Termination of Pregnancy with Fetal Death in Second and Early Tird Trimester of Pregnancy
Journal Title: Sultan Qaboos University Medical Journal - Year 2008, Vol 8, Issue 3
Abstract
To study the efficacy of intravenous sulprostone (Nalador) for the termination of pregnancy with fetal death in second and early third trimester of pregnancy. Methods: Tis is a retrospective collection and analysis of data from a cohort of 97 women with fetal death between 2-30 weeks gestation treated with intravenous infusion of a prostaglandin analogue, sulprostone, to achieve expulsion of the products of conception. It was conducted in the Department of Obstetrics and Gynaecology, Sultan Qaboos University Hospital, Oman. Te data collected was from January 2000 to December 2005. Sulprostone was started as an intravenous infusion of 5µgm/hr and titrated to a maximum of 240µgm/hr to a total dose of 500µgm/day, as per the departmental protocol. Te patients’ demographic data, gestational age, induction-expulsion interval, the need for evacuation, side effects and complications were studied. Results: Out of the 97 women who received sulprostone, 90 aborted within 24 hours. Te average induction-expulsion interval was .9 ± 8.0 hours. Sulprostone use was associated with few side effects and was well tolerated by patients. Although most of the patients required evacuation and curettage, the blood loss was minimal. Only six out of 97 women required blood transfusions and two patients needed hysterotomy. Conclusion: We found sulprostone an efficient drug for termination of pregnancy with fetal death in second and early third trimester of pregnancy.
Authors and Affiliations
Anita K Mohan| Department of Obstetrics and Gynecology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, Mariam Mathew| Department of Obstetrics and Gynecology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman, Syed G Rizvi| Department of Family Medicine & Public Health, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
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