Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant
Journal Title: Annals of Hepatology - Year 2016, Vol 15, Issue 2
Abstract
Background and rationale. Acoustic radiation force impulse (ARFI) is a non-invasive tool used in the evaluation of liver fibrosisin HCV positive immune-competent patients. This study aimed to assess the accuracy of ARFI in discriminating liver transplantedpatients with different graft fibrosis severity and to verify whether ARFI, eventually combined with non-invasive biochemical tests,could spare liver biopsies. This prospective study included 51 HCV positive liver transplanted patients who consecutively underwentto annual liver biopsy concomitantly with ARFI and blood chemistry tests measurements needed to calculate several non-invasive liver fibrosis tests. Results. Overall ARFI showed an AUC of 0.885 in discriminating between patients without or with significant fibrosis (Ishak score 0-2vs. 3-6). Using a cut-off of 1.365 m/s, ARFI possesses a negative predictive value of 100% in identifying patients without significant fibrosis. AUC for Fibrotest was 0.848 in discriminating patients with Ishak fibrosis score 0-2 vs. 3-6. The combined assessment of ARFI and Fibro-test did not improve the results obtained by ARFI alone. Conclusion. ARFI measurement in HCV positive liver transplanted patients can be considered an easy and accurate non-invasive tool in identify patients with a benign course of HCV recurrence.
Authors and Affiliations
Sara Bignulin, Edmondo Falleti, Dario Cappello, Annarosa Cussigh, Ilaria Lenisa, Denis Dissegna, Fabio Pugliese, Cinzia Vivarelli, Carlo Fabris, Pierluigi Toniutto
Keywords
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