Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant

Journal Title: Annals of Hepatology - Year 2016, Vol 15, Issue 2

Abstract

Background and rationale. Acoustic radiation force impulse (ARFI) is a non-invasive tool used in the evaluation of liver fibrosisin HCV positive immune-competent patients. This study aimed to assess the accuracy of ARFI in discriminating liver transplantedpatients with different graft fibrosis severity and to verify whether ARFI, eventually combined with non-invasive biochemical tests,could spare liver biopsies. This prospective study included 51 HCV positive liver transplanted patients who consecutively underwentto annual liver biopsy concomitantly with ARFI and blood chemistry tests measurements needed to calculate several non-invasive liver fibrosis tests. Results. Overall ARFI showed an AUC of 0.885 in discriminating between patients without or with significant fibrosis (Ishak score 0-2vs. 3-6). Using a cut-off of 1.365 m/s, ARFI possesses a negative predictive value of 100% in identifying patients without significant fibrosis. AUC for Fibrotest was 0.848 in discriminating patients with Ishak fibrosis score 0-2 vs. 3-6. The combined assessment of ARFI and Fibro-test did not improve the results obtained by ARFI alone. Conclusion. ARFI measurement in HCV positive liver transplanted patients can be considered an easy and accurate non-invasive tool in identify patients with a benign course of HCV recurrence.

Authors and Affiliations

Sara Bignulin, Edmondo Falleti, Dario Cappello, Annarosa Cussigh, Ilaria Lenisa, Denis Dissegna, Fabio Pugliese, Cinzia Vivarelli, Carlo Fabris, Pierluigi Toniutto

Keywords

Related Articles

Sustained virological response according to the type of early virological response in HCV and HCV/HIV

Background. The most important factors to predict the sustained virological response (SVR) are the genotype and the fibrosis grade, although there are other predictive factors to be considered, mainly in HCV/HIV coinfect...

Antioxidant effect of N-acetylcysteine on prehepatic portal hypertensive gastropathy in rats

Background. Portal hypertension is a clinical syndrome associated with the development of a hyperdynamic circulation and gastroesophageal varices. Aim. To evaluate the antioxidant effect of N-acetylcysteine on portal hyp...

Protective and curative effects of polyphenolic extracts from [i]Ichnocarpus frutescense[/i] leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen

The aim of this study was to investigate prophylactic and curative effect of polyphenolic extract of Ichnocarpus frutescense against carbon tetrachloride and tamoxifen induced hepatotoxicity in rats. Carbon tetrachloride...

Inter and intrapatient evolution of hepatitis C virus

Hepatitis C virus (HCV) has a short replication time, high mutation rates and large population sizes, all of which make it an excellent experimental model for evolution studies, because evolution can be visualized in rea...

Download PDF file
  • EP ID EP78556
  • DOI -
  • Views 122
  • Downloads 0

How To Cite

Sara Bignulin, Edmondo Falleti, Dario Cappello, Annarosa Cussigh, Ilaria Lenisa, Denis Dissegna, Fabio Pugliese, Cinzia Vivarelli, Carlo Fabris, Pierluigi Toniutto (2016). Usefulness of acoustic radiation force impulse and fibrotest in liver fibrosis assessment after liver transplant. Annals of Hepatology, 15(2), 200-206. https://europub.co.uk/articles/-A-78556