USEFULNESS OF CRP IN DIFFERENTIATING INFECTED FROM UNINFECTED NEONATES AS AMONG THOSE AT RISK OF INFECTION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 7
Abstract
Neonatal sepsis remains an important diagnostic consideration in many neonates, either because of risk factors or clinical manifestations associated with bacterial infection, which are unspecific and vague. It is important to differentiate infected from uninfected neonates among those at risk of infection due to maternal risk factors. Several surrogate markers of inflammation like CRP, Cytokine levels have been evaluated as possible tools for early diagnosis of bacterial sepsis. Such test could be of special importance in a newborn that is asymptomatic or has only equivocal signs at birth but has risk factors for infection. The present study was conducted to evaluate the effect of the intrapartum risk factors for early onset sepsis on CRP levels and utility of CRP in the diagnosis of EOS. A study of 108 neonates at risk of developing infection over a period of one year was done at tertiary Hospital, Khammam. CRP levels in cord blood and neonatal blood at 24-36 hrs. were estimated using commercial kits. Babies were observed for signs of sepsis for at least 72 hrs. Ten (9.3%) neonates had elevated CRP levels in the cord blood. Elevated cord CRP level showed positive association with primiparity, rupture of membranes more than 24 hrs, prolonged labor, maternal fever, more than three vaginal examinations, foul smelling liquor, urinary tract infection and babies extracted by LSCS. The negative predictive value for elevated CRP levels at 24 hrs. was 97%. Several intrapartum risk factors for EOS can cause elevation in CRP levels however; this test may be useful in excluding infection. CRP level is a good indicator, in diagnosing the early sepsis and early intervention in management of neonatal sepsis, intern it prevents mortality in neonates.
Authors and Affiliations
Somaiah , Vamsidhar , Sujitha , Mohan Rao, Srikanth K
Keywords
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- EP ID EP90100
- DOI 10.14260/jemds/2014/2049
- Views 77
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