Usefulness of Serum and Urinary Neutrophil Gelatinase -Associated Lipocalin in Detecting Acute Kidney Injury in Asphyxiated Neonates
Journal Title: International Journal of Medical and Health Sciences - Year 2016, Vol 5, Issue 4
Abstract
Objective: To determine the predictive value of serum and urinary NGAL in the detection of AKI in asphyxiated neonates. Subjects and Methods: Serum and uNGAL were measured in forty full term>37 week, both sexes, neonates had clinical and laboratory findings of perinatal asphyxia according to the criteria defined by the American Academy of Pediatrics and 20 apparently healthy neonates matched for gestational age and birth weight as a control group, in the neonatal intensive care unit of Benha university hospital within 24 hours after birth using ELISA. Results: Asphyxiated neonates had significantly higher serum NGAL and uNGAL than control neonates, (P<0.001). Serum and uNGAL level were higher in patients with AKI than those without AKI; (P<0.001). Serum and urinary NGAL correlated with serum creatinine at the day 3 in the AKI subgroup. A cutoff value 144 ng/ml for serum NGAL and a cutoff value 18 ng/ml for urinary NGAL could detect AKI in asphyxiated neonates with a sensitivity of 95% and a specificity of 94%. Conclusion: Serum and urinary NGAL obtained in the first 24 hours of life showed significantly high values in asphyxiated neonates, with great accuracy and high sensitivity and specificity.
Authors and Affiliations
Soha Abdelhady, Eman R. Abdel Gawad, Omima M. Abdel Haie, Amira I. Mansour
Keywords
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