Abstract

Aim of the work: residual kidney function (RKF) in end stage kidney disease (ESKD) patients contributes significantly to solute clearance. This improves survival as well quality of life in these patients. Kidney Diseases Outcomes Quality Initiative (KDOQI) guidelines suggest that hemodialysis (HD) dose can be safely reduced in those with RKF in the form of residual urea clearance (KRU) of 2 ml/min/1.73 m2 or more. However, measurement of RKU is difficult as it requires regular inter-dialytic urine collections. Simpler methods for measuring KRU and thus RKF are needed. Beta trace protein (BTP)have been proposed as alternative markers of RKF and RKU. Dialysis specific equations to estimate KRU based on serum BTP wererecentlydeveloped. This study aimed to compare measured KRU using inter-dialytic urine collection and estimated KRU using serum BTP.Patients and Methods: we included 60 ESKD patients in this study;they were divided into 2 groups. Group-1(G-1) had daily urine output <500ml and group-2(G-2) haddaily urine output >500ml. We estimated and measured KRU in both groups. Correlation between measured and estimated KRU in each group was done using Pearson correlation coefficient. Results: the estimated and measured KRU was strongly correlated in G-1 with r=0.746 at p<0.01 , but it was week in G-2 with r=0.44 and p<0.05.Mean bias between estimated and measured KRU was 0.7 mL/min in G-1. In G-2 the mean bias was -0.54mL/min. Conclusion: KRU and thus RKF can be better estimated using serum BTP in patients with urine output >500mL than in patients with daily urine output200-500mL.

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