Using the thermal methods of analysis in selecting the optimal production techniques for tablets based on ademetionine 1,4-butanedisulfonate substance
Journal Title: Фармацевтичний журнал - Year 2015, Vol 6, Issue 6
Abstract
When developing tablets on the base of ademetionine 1.4-butandionsulfonat substance it is difficult to obtain a stable product, as substance is hygroscopic, and its quantity in the tablet is 90% by weight of the core. The aim of our work was the choice of conditions which would assure the safety of physical and chemical properties of the substance in the production process and allowed to get quality product. Tablet mass was prepared by dry mixing, controlling the relative humidity in the range from 15 to 50% and a temperature from 15 to 25 °C. Studies were carried out by differential scanning calorimetry and the method for determining the weight of moisture. The results were compared with those obtained in studies for comparing drug Geptral (Abbott SpA, Italy). As a result of studies was found that study samples number 1 and number 2 are as close as possible to their thermodynamic properties to the comparing drug. However, achieving a relative humidity of 15% is costly compared with values reaching 20%. Thus in the case of serial production is sufficient to create the following conditions: relative humidity not above 20%, the temperature +20,0 ± 2,0 °C.
Authors and Affiliations
K. S. Burdak, T. G. Yarnyh, I. B. Yanchuk, G. I. Borschevskiy
Keywords
Related Articles
- EP ID EP586851
- DOI -
- Views 47
- Downloads 0
Synthesis and structural features of 5-(4-(tert-butyl) phenyl)-4-((R)amino)-4H-1,2,4-triazole-3-thiols
Chemistry of heterocyclic compounds is one of the most popular sector in organic chemistry. Scientists allocate among them a class of derivatives of 1,2,4-triazole. This class of compounds attracts attention his broad sp...
Andragogical approaches in postgraduate education
Andragogy is a section of learning theory, which reveals the specific patterns of development of knowledge and adult’s skills subject to training, and the specific of guiding the professional educator. The relevance and...
Research of amino acid aerial parts Polygonum persicaria L.
One of the most promising sources of amino acids are medicinal plants. Amino acids plant’s form a large group of organic compounds that have unique biological, pharmacological and toxicological properties. With a wide ra...
Thermogravimetric investigations of gel shampoo with minoxidil
On the department of technology of medications Zaporizhzhia State Medical University as a result of complex biopharmaceutical, physico-chemical and microbiological investigations the shampoo-gel with minoxidil 1% for the...
Prospects of medicinal mushroom Flammulina velutipes usage in medical and pharmaceutical practices
Nowadays, well known in East medicine different mushroom’s medicinal properties are widely used in medications and bioactive supplements for therapy of different diseases. The purpose of our study was to determinatate t...