Utility of AgNOR Count in Non-Neoplastic and Neoplastic Lesions of the Uterine Cervix
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Background: Uterine cervix is the most common site for occurrence of non-neoplastic and neoplastic lesions in female genital tract. Squamous cell neoplasia of the cervix is the most common malignant tumour in most developing countries. The aim of study was to evaluate the incidence of benign & malignant lesions of the uterine cervix and determining the grade of malignancy by AgNOR staining technique. Material & Methods: This study was carried out in the Department of Pathology, on material received from attached hospitals of SMS Medical College, Jaipur. A total of 210 cases of non-neoplastic and neoplastic lesions of uterine cervix were included. After processing, paraffin embedded sections of each case were stained with hematoxylin and eosin and separate sections from same block were utilized for AgNOR staining and results were recorded. Results: Our study showed that maximum 29 (82.85%) cases of chronic cervicitis were between 31-50 years of age and squamous hyperplasia (58.33%), squamous metaplasia (40%) & 50% cases in cervical intraepithelial neoplasia belonged to 41-50 years of age group. Majority of malignant cases (34.31%) were found between 41-50 years of age group. The moderately differentiated keratinizing SCC showed the range of AgNOR count 4.9-5.8 and mean AgNOR count was 5.20±0.42 with predominant type III dots. Statistical analysis revealed significant difference between the mean AgNOR count of Group A and Group B (P<0.001), group A and group D (P<0.001) and group B and group D (P<0.001). Conclusion: It was concluded that AgNOR staining is a very useful method as predictor of progression, but should be supplemented with other parameters.
Authors and Affiliations
Anita Harsh, Ramesh Tondon, Harsh Kumar Harsh
Keywords
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- EP ID EP529675
- DOI 10.21276/ijmrp.2018.4.1.039
- Views 57
- Downloads 0
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