Utility of DxH 800 VCS Parameters and Lymph Index in Predicting Dengue
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 8
Abstract
Abstract Introduction: Dengue is an acute febrile illness where high fever is accompanied by headache, arthralgia and myalgia. Volume, Conductivity and Scatter (VCS) positional parameters have been reported to be useful in indicating dengue infection. The derived indices like lymph index are being introduced to predict dengue. Aim: To evaluate diagnostic utility of lymph index and VCS positional parameters in dengue fever. Materials and Methods: Peripheral blood samples of 100 serology proven cases of dengue, 25 proven cases of malaria and 50 healthy controls were evaluated in Coulter DxH 800 automated analyser, VCS positional parameters were analysed, and lymph index was derived. Results: Lymphocytes, neutrophils and monocytes positional parameters were significantly different in dengue group when compared to the cases of malaria and healthy individuals, indicating morphological changes in leucocytes. The mean volume of lymphocytes, neutrophils and monocytes were significantly increased, whereas the mean conductivity of neutrophils and monocytes were significantly decreased in dengue. Lymph index was significantly increased (mean: 16.64±5.63) in cases of dengue as compared to control (mean: 11.56±1.68), and had a sensitivity of 73% and specificity of 88%. Conclusion: Lymph index, along with the positional parameters, the scatterplot, and the histogram, is a fairly accurate parameter in prediction of dengue in suspected cases and could be used to select cases for testing dengue.
Authors and Affiliations
Sharada Rai, Sonali Singh, Cheryl Sarah Philipose, Bryne Susan Mendonca, Vatsala K Basavaraju
Keywords
Related Articles
- EP ID EP638988
- DOI 10.7860/JCDR/2019/38500.13044
- Views 105
- Downloads 0
Role of Sonographic Gray-Scale Pattern Recognition in the Diagnosis of Adnexal Masses
Introduction: Characterization of adnexal masses as benign or malignant is of utmost importance for optimal management and prognostication. Ultrasound examination plays an important role in the differentiation of adnexal...
Intra and Inter-Observer Variability of Transformation Zone Assessment in Colposcopy: A Qualitative and Quantitative Study
Introduction: Colposcopy is an important tool in the diagnosis of cervical precancer and early cancer. The assessment of women with abnormal cytology and selection of those who require further therapy or follow up depend...
Peritonitis due to Galactomyces geotrichum: A Rare Case Report
ABSTRACT Galactomyces geotrichum is the teleomorphic stage of several unnamed Geotrichum species. They are filamentous yeast like fungi that are ubiquitous in nature. They have been isolated from various sources such as...
Hypocalcaemia Following Transfusion of a Small Volume of Red Blood Cell Concentrate: An Unusual Case
Letter to Editor
Pulpal Response to Ferric Sulfate and Diode Laser When Used as Pulpotomy Agent: An In vivo Study
Introduction: Ferric sulfate and Laser has been used for conventional pulpotomy therapy. Clinical and radiographic evaluation of pulpotomies using these have been done in numerous studies but there exists few studies ana...