UV-SPECTROPHOTOMETRIC DETERMINATION OF ROSUVASTATIN AND NIACIN INDIVIDUALLY AND COMBINED TABLET DOSAGE FORM BY SIMULTANEOUS EQUATION AND ABSORBANCE RATIO METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 6
Abstract
Two UV-spectrophotometric methods were developed and validated for quantitative determination of Rosuvastatin and niacin in combined tablet dosage form .Method I is based on the simultaneous equation and method II is based on the absorbance ratio method. The absorbance maxima were found to be at 241and 262nm in water for the Rosuvastatin and niacin respectively. Beer’s law is obeyed in the concentration range 5-40µg/ml with correlation coefficient within range of0.998 for both the drugs. The accuracy of the methods was assessed by recovery studies and found to be 98-105%for Rosuvastatin and niacin respectively.
Authors and Affiliations
Savita Narayankar , Promod Sakpal , Chandrashekhar Bhingare
Keywords
Related Articles
- EP ID EP137706
- DOI 10.7897/2230-8407.06671
- Views 69
- Downloads 0
FORMULATION AND EVALUATION OF LIQUISOLID COMPACTS OF AMLODIPINE BESYLATE
Amlodipine is a long-acting calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. Like other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial...
SELF EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW
Oral route still remains the favorite route of drug administration in many diseases and till today it is the first wayinvestigated in the development of new dosage forms. Approximately 40 per cent of new drug candidates...
IN VITRO ANTIBACTERIAL ACTIVITY STUDY OF ROSA INDICA LINN. LEAVES EXTRACTS
To know the in vitro antibacterial activity of both the ethanolic and methanolic extracts of the leaves of both Pink Rose and Maroon Rose varieties of Rosa indica (Family-Rosaceae), present study was conducted. Both the...
HEPATOPROTECTIVE ACTIVITY OF ARTOCARPUS HETEROPHYLLUS LAM. LEAVES AGAINST THIOACETAMIDE INDUCED HEPATOTOXICITY ON WISTAR ALBINO RATS
In the present study, the hepatoprotective activity of Artocarpus heterophyllus Lam. leaves was investigated against thioacetamide induced hepatotoxicity model in Wistar albino rats. The acute toxicity study showed that...
PHYTOCHEMICALAND ANTIOXIDANT STUDIESON THE ESSENTIAL OIL OF THE RHIZOME OF CURCUMA AERUGINOSAROXB.
The genus Curcuma, of Zingiberaceae, comprises of 80 species, some of which have been used in traditional systems of medicine (Ayurveda, Siddha, Unani) for a long time.The present investigation was conducted to examthe...