UV spectrophotometric estimation of sorafenib in pure and tablet dosage form
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 10
Abstract
Two simple, rapid, accurate, sensitive and precise spectrophotometric methods (A and B) in ultra violet region have been developed for determination of sorafenib in pure and tablet dosage form. In method A, sorafenib exhibited maximum absorbance at 265 nm with apparent molar absorptivity of 5.2539× 10 4 in acetonitrile. In method B sorafenib exhibited maximum absorbance at 271 nm with apparent molar absorptivity of 5.0216 × 10 4 in dimethyl sulfoxide (DMSO). Beer’s law was found to be obeyed in the concentration range 2-10 µg/mlin both methods. Correlation coefficient was found to be 0.999 for both methods. The developed method was validated respect to linearity, precision, accuracy. The proposed methods are useful for the routine estimation of sorafenib in pure and tablet dosage form.
Authors and Affiliations
Rama l i n g am Ka l a i c h e l v i 1 * and Ekambaram Jayachandran 2
Keywords
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