UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in Combined Dosage Form
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 4
Abstract
Aims: UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in combined Dosage form. Study Design: A simple, rapid and specific UV spectroscopic method with good sensitivity was developed and validated for the simultaneous determination of Desloratidine and Pseudoephedrine HCl in bulk and pharmaceutical dosage form. Place and Duration of Study: Department of pharmaceutical Analysis & Quality Assurance, School of Pharmacy, Anurag Group of Institutions, Venkatapur, R.R Dist, Andhra Pradesh, India during February 2013 and April 2013. Methodology: Vierodt’s (Simultaneous equation) method was performed for Estimation of Desloratidine and Pseudoephedrine HCl in Pharmaceutical dosage form. Results: In Ethanol the max of Desloratidine and Pseudoephedrine HCl was fixed as 240 and 258 nm respectively using a Shimadzu UV-Visible spectrophotometer. In this proposed method both drugs obeyed linearity within the concentration range of 5-30 g/ml and 80-800 g/ml for Desloratidine and Pseudoephedrine HCl respectively. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method has been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim. The method was validated as per ICH guidliness. Conclusion: The developed method was simple, accurate, precise, specific, sensitive and reproducible which can be efficiently and easily applied to pharmaceutical dosage forms.
Authors and Affiliations
K. Hussain Raviteja, Mahesh Nasare, V. V. L. N. Prasad, Prakash V. Diwan
Keywords
Related Articles
- EP ID EP344689
- DOI 10.9734/BJPR/2014/5615
- Views 99
- Downloads 0
Pharmacokinetics of Nevirapine in HIV Infected Children from Resource Limited Settings Using Fixed Dose Anti-retroviral Combinations
Introduction: The pharmacokinetics of nevirapine in paediatric populations are important to consider for those receiving anti-retroviral treatment in resource limited settings. High rate of adherence is required to achie...
Quality Assessment of Some Brands of Tetanus Toxoids Marketed in Open Markets in South-Eastern Nigeria
Aims: This study was designed to verify the immunogenicity (potency) and the safety of tetanus toxoid vaccines marketed in three large open drug markets in South-Eastern Nigeria. Methodology: Tests for Sterility, formald...
Biocompatible and Biodegradable Chitosan / Clay Nanocomposites as New Carriers for Theophylline Controlled Release
Aims: Carrier polymeric materials based on chitosan and chitosan / montmorillonite crosslinked with glutaraldehyde were prepared and studied for their biocompatibility, nontoxicity, and biodegradability aiming their appl...
The Role of Aripiprazole (An Anti-psychotic Drug) in the Resolution of Acute Peripheral Inflammation in Male Wistar Rats
Aripiprazole, a known second generation anti-psychotic drug has been implicated to possess an anti-inflammatory potential, but yet not scientific adequately explored. This study investigated the role of aripiprazole in t...
Development of Anti-bacterial Ointment from Two Extracts of Curcuma longa L. and Aloe vera L.
Aim of this Study: This study aimed to extract, formulate and evaluate an antibacterial ointment from extracts of two Yemeni plants. Methods: The extraction of both Curcuma longa and Aloe vera was performed using alcohol...