UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in Combined Dosage Form
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 4
Abstract
Aims: UV Spectrophotometric Method for the Simultaneous Determination of Desloratidine and Pseudoephedrine HCl in combined Dosage form. Study Design: A simple, rapid and specific UV spectroscopic method with good sensitivity was developed and validated for the simultaneous determination of Desloratidine and Pseudoephedrine HCl in bulk and pharmaceutical dosage form. Place and Duration of Study: Department of pharmaceutical Analysis & Quality Assurance, School of Pharmacy, Anurag Group of Institutions, Venkatapur, R.R Dist, Andhra Pradesh, India during February 2013 and April 2013. Methodology: Vierodt’s (Simultaneous equation) method was performed for Estimation of Desloratidine and Pseudoephedrine HCl in Pharmaceutical dosage form. Results: In Ethanol the max of Desloratidine and Pseudoephedrine HCl was fixed as 240 and 258 nm respectively using a Shimadzu UV-Visible spectrophotometer. In this proposed method both drugs obeyed linearity within the concentration range of 5-30 g/ml and 80-800 g/ml for Desloratidine and Pseudoephedrine HCl respectively. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method has been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim. The method was validated as per ICH guidliness. Conclusion: The developed method was simple, accurate, precise, specific, sensitive and reproducible which can be efficiently and easily applied to pharmaceutical dosage forms.
Authors and Affiliations
K. Hussain Raviteja, Mahesh Nasare, V. V. L. N. Prasad, Prakash V. Diwan
Keywords
Related Articles
- EP ID EP344689
- DOI 10.9734/BJPR/2014/5615
- Views 114
- Downloads 0
A New Emulsifying Agent: Cucumis sativus Linnaeus Mucilage
Aim: This study aims at investigating the emulsifying properties of Cucumis sativus mucilage, compare with gelatin and tragacanth with further assessment of their combined effects on the emulsion properties. Place and D...
Kigelia africana Stem Bark, Fruit and Leaf Extracts Alleviate Benzene-induced Leukaemia in Rats
Aims: This study was aimed at evaluating the potential leukaemia chemotherapeutic activities of various extracts of Kigelia africana stem bark; fruit and leaf by using a benzene-induced model of leukaemia to validate its...
Immunization Services: Involvement of Community Pharmacies in Lagos State, Nigeria
Aims: The aim of this study was to evaluate the current practice of Community Pharmacies in immunization services, and evaluate the level of willingness of Community Pharmacists to participate in immunization services. S...
Rapid, Simple and Validated Method for Estimation of Zolpidem by UPLC in Tablet Dosage Form
Aim: To create and approve a novel and fast RP-UPLC technique for the estimation of zolpidem in tablet dosage form. Place and Duration of Study: Department of pharmaceutical analysis, S.V.S. school of Pharmacy, Bheemaram...
Phytochemical and Antimicrobial Properties of the Hexane and Ethanol Leaf Extract of Pterocarpus Erinaceous poir (Fabaceae)
This study evaluated the phytochemical and antimicrobial properties of the hexane and ethanol leaf extract of Pterocarpus erinaceous poir (Fabaceae). Ethno medicinally, the leaves are used in treatment of conjunctivitis,...