UV-spectrophotometric study of the 7-((3-thio-4-R-1,2,4-triazole-3-yl)methyl)-theophyllines
Journal Title: Фармацевтичний журнал - Year 2015, Vol 4, Issue 4
Abstract
Chemistry of the 1,2,4-triazole derivatives recently attracts the attention of many scientists, mainly due to the presence of the number of the valuable pharmacological properties. In modern medical practice, there are many examples of successful heterocyclic systems derivatives usage. First of all, it is a group of drugs with antifungal activity (fluconazole, itraconazole, voriconazole, pozakonazol), antidepressant activity (alprazolam, triazolam), anticancer activity (anastrozole, letrozole). But despite the great practical importance of works in this area, the structure of 1,2,4-triazoles-3-thione derivatives have been studied imperfectly. Therefore, the study of this class of compounds is actual now. The aim of this work was to study the UV-spectra of the research compounds in different polarity solvents (water, 95% ethanol, 0,1 M and 1 M sodium hydroxide, 0,1 M and 1 M hydrochloric acid, 0,1 M and 1 M sulfate acid solution, chloroform, isopropanol, acetonitrile and dioxane) for structure–spectral data relationship establishing. Spectrophotometer SPECORD 200-222U214 was used to study the UV-spectra of the analyzed compounds and to measure their intensity. During the research, it was found that the electronic spectra of 7-((3-thio-4-methyl-1,2,4-triazoles-5-yl)methyl)theophylline, 7-((3-thio-4-ethyl-1,2,4-triazolе-5-yl)methyl)theophylline and 7-((3-thio-4-phenyl-1,2,4-triazolе-5-yl)methyl)-theophylline were characterized by maximums in the short-wave (203–235 nm) and medium-wavе part (250–272 nm) of UV-spectrum. Due to the presence of the methylene fragment in investigated molecules, which connects the purine cycle with 1,2,4-triazole, absorbtion maximums were caused by π→π*-electron jumping of the corresponding type 1La and 1Lb.
Authors and Affiliations
A. S. Gotsulya, O. I. Panasenko, Ye. G. Knysh, A. O. Pryimenko
Keywords
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